Cognitive & Nootropic

Pentadecapeptide derived from a gastric protein; widely used in research and compounding for tendon, gut, and soft-tissue repair.

Synthetic ACTH(4-10) analog developed in Russia for stroke rehabilitation and cognitive enhancement.

Synthetic tuftsin analog with anxiolytic and immunomodulatory effects, developed as a non-benzodiazepine alternative.

Choline-delivery compound that raises brain choline and acetylcholine levels, commonly used as a nootropic.

Angiotensin IV analog with potent synaptogenic activity in preclinical models; potency much higher than BDNF in some assays.

Potent sympathomimetic stimulant once sold in pre-workout supplements; banned by the FDA in dietary supplements due to safety concerns.

Fluorinated analog of adrafinil/modafinil with similar wakefulness-promoting effects. Research chemical status.

Oral triple monoamine reuptake inhibitor investigated for obesity; shows substantial weight loss in trials.

GABA-B and alpha-2-delta ligand used for anxiety and sleep. Significant dependence and withdrawal risk.

Acetylated Selank analog with improved half-life and oral/intranasal stability.

Acetylated Semax analog with improved stability and bioavailability.

Short peptide derived from a ciliary neurotrophic factor fragment, investigated for neurogenesis and cognitive enhancement.

Porcine brain-derived multi-peptide preparation with neurotrophic-factor-like activity. Used in ~50 countries for stroke, TBI, and vascular dementia.

Dipeptide-ester nootropic (Russian Rx) that metabolizes to cycloprolylglycine and elevates BDNF/NGF.

Russian actoprotector / mild psychostimulant-anxiolytic that upregulates tyrosine and tryptophan hydroxylase to raise dopamine and serotonin synthesis.

ADNP-derived microtubule-stabilizing octapeptide. Phase 2/3 PSP trial failed primary endpoint; orphan drug designation retained for ADNP syndrome.

Khavinson brain-cortex tetrapeptide (AEDP) derived from Cortexin extract. Regulates nerve-regeneration genes and modulates IL-2 mRNA.

11-amino-acid peptide derived from the erythropoietin molecule that selectively activates the innate repair receptor (IRR) without erythropoietic activity. Investigated for neuropathic pain, sarcoidosis, and diabetic neuropathy.

Nine-amino-acid neuropeptide with established FDA approval for labor induction and milk letdown, plus extensive off-label use as an intranasal compound for social bonding, anxiety, and trauma-related applications.