Mitochondrial & Metabolic

Mitochondrial-derived peptide that acts as an exercise mimetic, improving insulin sensitivity and metabolic flexibility.

Tetrapeptide that targets the inner mitochondrial membrane, stabilizes cardiolipin, and improves ATP production in dysfunctional mitochondria.

Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that increases intracellular NAD+ and SAM and may reduce adiposity.

Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways.

Mitochondrial-derived peptide with cytoprotective effects across neurons, cardiomyocytes, and beta cells; a candidate longevity signaling peptide.

PPARδ agonist that increases fatty-acid oxidation and endurance in preclinical models. Development halted over carcinogenicity findings in rats.

Mitochondrial protonophore that uncouples oxidative phosphorylation to increase metabolic rate without the cardiac risk profile of DNP.

Amino acid derivative that shuttles long-chain fatty acids into mitochondria for oxidation; used IM or orally in fat loss and energy protocols.

Compounded injectable blend of lipotropic amino acids and B-vitamins, commonly used in weight-management clinics.

Long-known synthetic dye with electron-shuttling activity; used off-label for mitochondrial support and cognition.

Compounded blend combining MOTS-C and SS-31 in a single vial for a broad mitochondrial intervention.

Pan-ERR (estrogen-related receptor) agonist that mimics exercise-induced metabolic adaptations in preclinical models.

Proprietary oral capsule blend marketed for mitochondrial and metabolic support. Composition varies between vendors.

Mitochondrial-derived peptide (~26 aa from 16S rRNA) that enhances mitochondrial metabolism and insulin sensitivity.

Mitochondrial-derived peptide that, in contrast to SHLP-2, is pro-apoptotic in cancer cell lines: a candidate tumor-suppressive MDP.

Macrolide mTORC1 inhibitor, FDA-approved for transplant rejection and LAM; weekly off-label dosing extends lifespan in mice and showed benefits in the PEARL human trial.

FDA-approved (1996) for aphthous ulcers; repurposed for obesity/T2D with modest weight loss and improved glycemia in human pilot studies.

Urolithin A is generated by gut bacteria metabolizing ellagitannins (pomegranate, berries). Direct supplementation induces mitophagy and improves muscle endurance in RCTs.

Lipophilic cation that enriches ubiquinol in the inner mitochondrial membrane to scavenge ROS; improves endothelial function in older adults.

Plant flavonol with senolytic activity. Extended murine lifespan ~10–17%; multiple human trials active.