Immune & Senolytic

Tripeptide fragment of alpha-MSH with potent anti-inflammatory effects, especially in the gut and skin.

Thymic peptide that enhances T-cell maturation and innate immune function; approved in several countries for hepatitis and as an adjuvant.

Tetrapeptide developed by Russian researcher Khavinson; investigated for telomerase activation and pineal function support.

Synthetic peptide that selectively induces apoptosis in senescent cells by disrupting FOXO4–p53 interaction.

Complex of thymic peptides developed in Russia for immune restoration and geriatric use.

Tripeptide (EDR) from the Khavinson group, proposed to support cognitive function and circadian regulation.

Synthetic 28-aa vasoactive intestinal peptide. FDA denied EUA twice for COVID-19; orphan designation for ARDS and pulmonary hypertension.

Endogenous 37-aa cationic antimicrobial peptide with immunomodulatory, wound healing, and angiogenic effects.

Khavinson brain-cortex tetrapeptide (AEDP) derived from Cortexin extract. Regulates nerve-regeneration genes and modulates IL-2 mRNA.

Khavinson thymus-derived dipeptide (Lys-Glu). Activates IL-2 synthesis and T-cell function; reports of murine lifespan extension.

Khavinson liver-derived tetrapeptide. Activates ribosomal gene transcription and decondenses heterochromatin in senescent lymphocytes.

Khavinson vascular tripeptide (KED) proposed to restore endothelial function and reduce vascular-aging markers.

Khavinson bronchial/lung-derived tripeptide. Modulates monocyte/macrophage proliferation and downregulates adhesion molecules and IL-6.

Khavinson liver/bronchi tripeptide proposed to modulate hepatocyte proliferation and immune-cell activity. Studied for chronic hepatitis.

Bovine prostate polypeptide complex (Samprost). Used in Russia/CIS for BPH and chronic prostatitis.

Khavinson testis-derived tetrapeptide. Marketed as supplement; no indexed clinical trials.

Senolytic drug combination that clears senescent cells via complementary pathways. Human pilot showed reduced senescent cell markers in diabetic kidney disease.

Zinc-dependent nonapeptide (FTS) secreted by thymic epithelial cells. Activity absolutely requires a bound zinc ion; 'Zn-thymulin' is the active form. Studied for immune restoration, allergic disease, and neuroinflammation.

Synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to residues 32–36 of thymopoietin. Approved in Italy and China for immune modulation in chronic infection, rheumatoid arthritis, and hepatitis B; not FDA-approved.