Longevity & Anti-Aging

Mitochondrial-derived peptide that acts as an exercise mimetic, improving insulin sensitivity and metabolic flexibility.

Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways.

Tetrapeptide developed by Russian researcher Khavinson; investigated for telomerase activation and pineal function support.

Mitochondrial-derived peptide with cytoprotective effects across neurons, cardiomyocytes, and beta cells; a candidate longevity signaling peptide.

Synthetic peptide that selectively induces apoptosis in senescent cells by disrupting FOXO4–p53 interaction.

Anti-aging protein / hormone whose decline with age is implicated in multiple age-related diseases.

Autophagy-inducing peptide that enhances Beclin-1 activity, studied for neurodegeneration and infection in preclinical models.

Tripeptide (EDR) from the Khavinson group, proposed to support cognitive function and circadian regulation.

Mitochondrial-derived peptide (~26 aa from 16S rRNA) that enhances mitochondrial metabolism and insulin sensitivity.

Mitochondrial-derived peptide that, in contrast to SHLP-2, is pro-apoptotic in cancer cell lines: a candidate tumor-suppressive MDP.

Macrolide mTORC1 inhibitor, FDA-approved for transplant rejection and LAM; weekly off-label dosing extends lifespan in mice and showed benefits in the PEARL human trial.

Urolithin A is generated by gut bacteria metabolizing ellagitannins (pomegranate, berries). Direct supplementation induces mitophagy and improves muscle endurance in RCTs.

Lipophilic cation that enriches ubiquinol in the inner mitochondrial membrane to scavenge ROS; improves endothelial function in older adults.

Khavinson brain-cortex tetrapeptide (AEDP) derived from Cortexin extract. Regulates nerve-regeneration genes and modulates IL-2 mRNA.

Khavinson thymus-derived dipeptide (Lys-Glu). Activates IL-2 synthesis and T-cell function; reports of murine lifespan extension.

Khavinson liver-derived tetrapeptide. Activates ribosomal gene transcription and decondenses heterochromatin in senescent lymphocytes.

Khavinson vascular tripeptide (KED) proposed to restore endothelial function and reduce vascular-aging markers.

Khavinson cartilage-derived tetrapeptide (from Sigumir). Proposed to stimulate chondrocyte proliferation and type-II collagen synthesis.

Senolytic drug combination that clears senescent cells via complementary pathways. Human pilot showed reduced senescent cell markers in diabetic kidney disease.

Plant flavonol with senolytic activity. Extended murine lifespan ~10–17%; multiple human trials active.