§ 01 Overview
Overview
PEGylated 24-aa IGF-1Ec E-peptide that activates muscle satellite cells via a non-IGF-1R pathway. Grey-market use with no registered trials.
Goldspink lab characterization. No registered clinical trials.
§ 02 Mechanism
Mechanism of action
Mechano Growth Factor (MGF) is the C-terminal E-peptide of the IGF-1Ec splice variant, produced by muscle after mechanical overload. It activates satellite cell proliferation through a receptor distinct from IGF-1R. PEGylation extends half-life for exogenous use.
- 01Satellite cell proliferation after mechanical overload
- 02PEGylation improves half-life vs. native MGF
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 200 – 400 mcg per dose (anecdotal)
- Route
- SubQ
- Timing
- Post-workout
- Frequency
- Training days
- Cycle
- 4–8 weeks
§ 04 Evidence
Evidence & research
Goldspink lab characterization. No registered clinical trials.
FDA Status
Not FDA-approved. WADA prohibited.
§ 06 News
In the news
3 articles from the last 12 months · updates hourly
PEG-MGF Peptide: A Molecular Signal with Expanding Possibilities in Regenerative and Cellular Research - The Sunday Guardian
PEG-MGF Peptide: A Molecular Signal with Expanding Possibilities in Regenerative and Cellular Research The Sunday Guardian
The Peptide Reclassification Everyone's Talking About: A Pharmacist's Take on What RFK Jr's Announcement Actually Means - Pharmacy Times
The Peptide Reclassification Everyone's Talking About: A Pharmacist's Take on What RFK Jr's Announcement Actually Means Pharmacy Times
The Properties Of Peptides – Research And Further Information 2026 - The Steeple Times
The Properties Of Peptides – Research And Further Information 2026 The Steeple Times
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Injection site reactions
- 02Unknown long-term safety
Contraindications
None specified.
§ 10 Questions
PEG-MGF FAQ
- What is PEG-MGF?
- PEGylated 24-aa IGF-1Ec E-peptide that activates muscle satellite cells via a non-IGF-1R pathway. Grey-market use with no registered trials. Mechano Growth Factor (MGF) is the C-terminal E-peptide of the IGF-1Ec splice variant, produced by muscle after mechanical overload. It activates satellite cell proliferation through a receptor distinct from IGF-1R. PEGylation extends half-life for exogenous use.
- What is PEG-MGF used for?
- Reported uses include satellite cell proliferation after mechanical overload and pegylation improves half-life vs. native mgf. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is PEG-MGF dosed?
- Commonly referenced dosing is 200 – 400 mcg per dose (anecdotal), typically training days, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of PEG-MGF?
- Commonly reported side effects include injection site reactions and unknown long-term safety. This list is not exhaustive.
- Is PEG-MGF legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. WADA prohibited..
§ 11 References
Selected references
- 01
Yang & Goldspink FEBS Lett
PMID: 12471024
- 02
Goldspink JMNI 2007
PMID: 17062699