§ 01 Overview
Overview
Pentadecapeptide derived from a gastric protein; widely used in research and compounding for tendon, gut, and soft-tissue repair.
Extensive rodent studies from the Sikiric group. Limited controlled human trials. FDA explicitly placed BPC-157 on the 503A Negative List in 2023.
§ 02 Mechanism
Mechanism of action
BPC-157 upregulates growth hormone receptor expression in tendon fibroblasts, promotes VEGFR2 signaling and angiogenesis, stabilizes the nitric oxide system, and modulates dopaminergic and serotonergic pathways.
- 01Accelerated tendon and ligament healing in preclinical models
- 02Gut mucosal healing (IBD models)
- 03Anti-inflammatory effects
- 04Neuroprotective signaling in animal models
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 250 – 500 mcg per dose
- Starting Dose
- 250 mcg 2x daily
- Route
- SubQ
- Timing
- AM and PM, near injury site when possible
- Frequency
- Daily, 1–2x/day
- Cycle
- 4–6 weeks, reassess
Storage
Refrigerate reconstituted vial.
§ 04 Evidence
Evidence & research
Extensive rodent studies from the Sikiric group. Limited controlled human trials. FDA explicitly placed BPC-157 on the 503A Negative List in 2023.
FDA Status
Not FDA-approved. FDA placed on the Section 503A Negative List; compounding is restricted.
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
BPC-157 Just Took Its Biggest Step Toward the Medical Mainstream: California Trim Clinic Opens the Conversation - FinancialContent
BPC-157 Just Took Its Biggest Step Toward the Medical Mainstream: California Trim Clinic Opens the Conversation FinancialContent
BPC Praises FDA Advisory Committee's Favorable Vote on BPC-157 and KPV for 503A Bulks List Inclusion - Kalkine Media
BPC Praises FDA Advisory Committee's Favorable Vote on BPC-157 and KPV for 503A Bulks List Inclusion Kalkine Media
Pro ultrarunner opens up about taking banned peptide - Canadian Running Magazine
Pro ultrarunner opens up about taking banned peptide Canadian Running Magazine
FDA Advisory Panel Votes to Allow Compounding Pharmacies to Produce BPC-157 - thesunpapers.com
FDA Advisory Panel Votes to Allow Compounding Pharmacies to Produce BPC-157 thesunpapers.com
America Is About to Go Over a Peptide Cliff - The Atlantic
America Is About to Go Over a Peptide Cliff The Atlantic
Peptide Compounding Vote Raises New Questions for Drug Developers - PharmTech.com
Peptide Compounding Vote Raises New Questions for Drug Developers PharmTech.com
FDA Advisory Panel Votes to Loosen Rules on BPC-157, TB-500, and MOTS-C Despite Agency Scientists' Opposition - Medical Daily
FDA Advisory Panel Votes to Loosen Rules on BPC-157, TB-500, and MOTS-C Despite Agency Scientists' Opposition Medical Daily
Regulatory loophole allows doctors to prescribe an unauthorized peptide - CBC
Regulatory loophole allows doctors to prescribe an unauthorized peptide CBC
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
503B pharmacies · 1
Hallandale Pharmacy (Pharmcore)
Rx required503A with historic warning letter (2020, closed out 2022). Major telehealth fulfillment partner.
Telehealth (Rx) · 3
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Marek Health
Rx requiredPremium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.
Blokes / Joi Women's Wellness
Rx requiredMen's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.
International · 5
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Direct Peptides
Multi-region geo-routed mirrors. Multiple credible scam complaints. Documented customs seizures. Avoid absent stronger evidence.
Pharma Lab Global
Budget pricing but significant QC concerns. Claims HPLC+MS 'on request' not displayed.
Canlab
Health Canada public warning December 2023. Operates across mirror domains to evade takedowns. Avoid.
Research-use-only · 7
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Ascension Peptides
Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.
Modern Aminos
Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.
Peptide Warehouse
US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.
BioTech Peptides
Claims >99% purity via HPLC + MS. Accepts cards and PayPal. 30-day money-back.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Generally well tolerated in research
- 02Mild injection site irritation
- 03Unknown long-term safety
Contraindications
None specified.
§ 10 Questions
BPC-157 FAQ
- What is BPC-157?
- Pentadecapeptide derived from a gastric protein; widely used in research and compounding for tendon, gut, and soft-tissue repair. BPC-157 upregulates growth hormone receptor expression in tendon fibroblasts, promotes VEGFR2 signaling and angiogenesis, stabilizes the nitric oxide system, and modulates dopaminergic and serotonergic pathways.
- What is BPC-157 used for?
- Reported uses include accelerated tendon and ligament healing in preclinical models, gut mucosal healing (ibd models), anti-inflammatory effects, and neuroprotective signaling in animal models. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is BPC-157 dosed?
- Commonly referenced dosing is 250 – 500 mcg per dose, typically daily, 1–2x/day, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute BPC-157?
- For BPC-157, vials commonly come in 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of BPC-157?
- Commonly reported side effects include generally well tolerated in research, mild injection site irritation, and unknown long-term safety. This list is not exhaustive.
- Is BPC-157 legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. FDA placed on the Section 503A Negative List; compounding is restricted..
§ 11 References
Selected references
- 01
BPC-157 accelerates Achilles tendon healing (rats)
J Orthop Res 2003