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Peptide.Guide

FDA Category 2 · restricted from compounding

This compound is on the FDA’s interim Section 503A Category 2 bulks list and cannot be legally compounded by US pharmacies. An HHS announcement in February 2026 signaled intent to restore several peptides to Category 1, but no Federal Register action has been published. Check the FDA PCAC schedule for updates.

Read the full regulatory context
PreclinicalTissue RepairOralDaily

KPV

Tripeptide fragment of alpha-MSH with potent anti-inflammatory effects, especially in the gut and skin.

Read dosing protocol

§ 01   Overview

Overview

Tripeptide fragment of alpha-MSH with potent anti-inflammatory effects, especially in the gut and skin.

Robust preclinical data; early clinical work in IBD.

§ 02   Mechanism

Mechanism of action

KPV is the C-terminal tripeptide of α-MSH. It enters cells and reaches the nucleus to suppress NF-κB signaling, reducing pro-inflammatory cytokine expression without the pigmentation effects of full-length α-MSH.

  • 01Anti-inflammatory in colitis models
  • 02Reduced skin inflammation and acne (topical/oral)
  • 03Supports gut barrier function

§ 03   Dosing

Dosing protocol

Standard Protocol

Vial
10 mg
BAC Water
N/A (capsule) or 2 ml BAC (injectable)
Dose Range
250 – 500 mcg oral; 250 mcg SubQ
Route
Oral
Timing
AM
Frequency
Daily
Cycle
4–8 weeks

§ 04   Evidence

Evidence & research

Preclinical

Robust preclinical data; early clinical work in IBD.

FDA Status

Not FDA-approved.

§ 05   Stacks

Common stacks

BPC-157

Gut healing combo

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Restricted from compounding

Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.

Research-use-only · 2

Research-use-only

Limitless Life Nootropics

'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.

BBB Accredited +1
Visit
Research-use-only

Ascension Peptides

Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.

Third-Party Testing
Visit

Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Well tolerated in research

Contraindications

None specified.

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04

BPC-157 (Capsules)

Oral capsule form of BPC-157, targeting gut healing where local action is desirable.

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05

BPC-157 + KPV (Capsules)

Combination oral capsule stacking BPC-157 and KPV for gut mucosal healing and anti-inflammatory effects.

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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.