§ 01 Overview
Overview
Tripeptide fragment of alpha-MSH with potent anti-inflammatory effects, especially in the gut and skin.
Robust preclinical data; early clinical work in IBD.
§ 02 Mechanism
Mechanism of action
KPV is the C-terminal tripeptide of α-MSH. It enters cells and reaches the nucleus to suppress NF-κB signaling, reducing pro-inflammatory cytokine expression without the pigmentation effects of full-length α-MSH.
- 01Anti-inflammatory in colitis models
- 02Reduced skin inflammation and acne (topical/oral)
- 03Supports gut barrier function
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 10 mg
- BAC Water
- N/A (capsule) or 2 ml BAC (injectable)
- Dose Range
- 250 – 500 mcg oral; 250 mcg SubQ
- Route
- Oral
- Timing
- AM
- Frequency
- Daily
- Cycle
- 4–8 weeks
§ 04 Evidence
Evidence & research
Robust preclinical data; early clinical work in IBD.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Pre-match VIFK vs KPV, Ykkosliiga Round 18 - BeSoccer Livescore
Pre-match VIFK vs KPV, Ykkosliiga Round 18 BeSoccer Livescore
KPV Table - Standings, Points, League Position - Forza Football
KPV Table - Standings, Points, League Position Forza Football
Pre-match TPS vs KPV, Suomen Cup Semi-finals - BeSoccer Livescore
Pre-match TPS vs KPV, Suomen Cup Semi-finals BeSoccer Livescore
Ykkonen (Finland) Tips and Stats for Today - AFootballReport
Ykkonen (Finland) Tips and Stats for Today AFootballReport
KPV Kokkola - Inter Turku 2 - Flashscore.com
KPV Kokkola - Inter Turku 2 Flashscore.com
Pre-match KPV vs Warkaus JK, Kakkonen Round 13 - BeSoccer Livescore
Pre-match KPV vs Warkaus JK, Kakkonen Round 13 BeSoccer Livescore
KPV/Akatemia vs Sporting Kristina live score, H2H and lineups - Sofascore
KPV/Akatemia vs Sporting Kristina live score, H2H and lineups Sofascore
Pre-match VIFK vs KPV, Ykkosliiga Round 16 - BeSoccer Livescore
Pre-match VIFK vs KPV, Ykkosliiga Round 16 BeSoccer Livescore
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Research-use-only · 2
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Ascension Peptides
Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Well tolerated in research
Contraindications
None specified.
§ 10 Questions
KPV FAQ
- What is KPV?
- Tripeptide fragment of alpha-MSH with potent anti-inflammatory effects, especially in the gut and skin. KPV is the C-terminal tripeptide of α-MSH. It enters cells and reaches the nucleus to suppress NF-κB signaling, reducing pro-inflammatory cytokine expression without the pigmentation effects of full-length α-MSH.
- What is KPV used for?
- Reported uses include anti-inflammatory in colitis models, reduced skin inflammation and acne (topical/oral), and supports gut barrier function. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is KPV dosed?
- Commonly referenced dosing is 250 – 500 mcg oral; 250 mcg SubQ, typically daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute KPV?
- For KPV, vials commonly come in 10 mg and a common reconstitution is N/A (capsule) or 2 ml BAC (injectable). Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of KPV?
- Commonly reported side effects include well tolerated in research. This list is not exhaustive.
- Is KPV legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved..