§ 01 Overview
Overview
Synthetic fragment of thymosin beta-4 promoting actin regulation, cell migration, and tissue repair.
Strong preclinical literature; limited human clinical data. WADA-banned for athletes.
§ 02 Mechanism
Mechanism of action
TB-500 sequesters G-actin and regulates actin polymerization, enabling endothelial and stem cell migration to sites of injury. It promotes angiogenesis and downregulates inflammatory mediators.
- 01Accelerated soft tissue recovery in animal models
- 02Supports cardiac and vascular repair (preclinical)
- 03Often stacked with BPC-157 for synergy
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg or 10 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 2 – 5 mg per week (split doses)
- Starting Dose
- 2 mg weekly split EOD
- Route
- SubQ
- Timing
- Any time
- Frequency
- 2–3x per week
- Cycle
- Loading 4–6 weeks, maintenance 2 mg/week
§ 04 Evidence
Evidence & research
Strong preclinical literature; limited human clinical data. WADA-banned for athletes.
FDA Status
Not FDA-approved. WADA prohibited at all times.
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Meet the doctors prescribing experimental peptides such as TB-500 and BPC-157 to athletes and executives - AFR
Meet the doctors prescribing experimental peptides such as TB-500 and BPC-157 to athletes and executives AFR
Pickleball, Peptides, Biohacker Heat: California Trim Clinic Says Wolverine Season Has Reached Utah - PR Underground
Pickleball, Peptides, Biohacker Heat: California Trim Clinic Says Wolverine Season Has Reached Utah PR Underground
Dr. Anthony Youn says popular peptides ‘aren’t studied enough’ in humans - NewsNation
Dr. Anthony Youn says popular peptides ‘aren’t studied enough’ in humans NewsNation
Are Peptides Such as BPC-157 and TB-500 Safe and Effective? - ConsumerLab.com
Are Peptides Such as BPC-157 and TB-500 Safe and Effective? ConsumerLab.com
What to Know About the 6 Peptides Backed by an FDA Advisory Panel - Verywell Health
What to Know About the 6 Peptides Backed by an FDA Advisory Panel Verywell Health
FDA Panel Recommends Compounding Unapproved Peptides - 조선일보
FDA Panel Recommends Compounding Unapproved Peptides 조선일보
Peptide Therapy: What the Science Shows About BPC-157, TB-500 and Wolverine Stacks - cedars-sinai.org
Peptide Therapy: What the Science Shows About BPC-157, TB-500 and Wolverine Stacks cedars-sinai.org
The F.D.A. Could Clear These Peptides. Here’s What the Research on Them Shows. - The New York Times
The F.D.A. Could Clear These Peptides. Here’s What the Research on Them Shows. The New York Times
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
503B pharmacies · 1
Hallandale Pharmacy (Pharmcore)
Rx required503A with historic warning letter (2020, closed out 2022). Major telehealth fulfillment partner.
Telehealth (Rx) · 1
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
International · 5
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Direct Peptides
Multi-region geo-routed mirrors. Multiple credible scam complaints. Documented customs seizures. Avoid absent stronger evidence.
Pharma Lab Global
Budget pricing but significant QC concerns. Claims HPLC+MS 'on request' not displayed.
Canlab
Health Canada public warning December 2023. Operates across mirror domains to evade takedowns. Avoid.
Research-use-only · 7
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Ascension Peptides
Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.
Modern Aminos
Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.
Peptide Warehouse
US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.
BioTech Peptides
Claims >99% purity via HPLC + MS. Accepts cards and PayPal. 30-day money-back.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Mild fatigue during loading
- 02Injection site bruising
Contraindications
None specified.
§ 10 Questions
TB-500 FAQ
- What is TB-500?
- Synthetic fragment of thymosin beta-4 promoting actin regulation, cell migration, and tissue repair. TB-500 sequesters G-actin and regulates actin polymerization, enabling endothelial and stem cell migration to sites of injury. It promotes angiogenesis and downregulates inflammatory mediators.
- What is TB-500 used for?
- Reported uses include accelerated soft tissue recovery in animal models, supports cardiac and vascular repair (preclinical), and often stacked with bpc-157 for synergy. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is TB-500 dosed?
- Commonly referenced dosing is 2 – 5 mg per week (split doses), typically 2–3x per week, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute TB-500?
- For TB-500, vials commonly come in 5 mg or 10 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of TB-500?
- Commonly reported side effects include mild fatigue during loading and injection site bruising. This list is not exhaustive.
- Is TB-500 legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. WADA prohibited at all times..