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Peptide.Guide

FDA Category 2 · restricted from compounding

This compound is on the FDA’s interim Section 503A Category 2 bulks list and cannot be legally compounded by US pharmacies. An HHS announcement in February 2026 signaled intent to restore several peptides to Category 1, but no Federal Register action has been published. Check the FDA PCAC schedule for updates.

Read the full regulatory context
PreclinicalLongevitySubQDaily

Epitalon

Epithalon · AEDG

Tetrapeptide developed by Russian researcher Khavinson; investigated for telomerase activation and pineal function support.

§ 01   Overview

Overview

Tetrapeptide developed by Russian researcher Khavinson; investigated for telomerase activation and pineal function support.

Russian studies report telomerase and lifespan effects. Limited independent replication in Western labs.

§ 02   Mechanism

Mechanism of action

Epitalon is hypothesized to induce telomerase expression and modulate pineal peptide signaling. Reported effects on melatonin rhythm and antioxidant enzymes in animal studies.

  • 01Telomere length support (preclinical)
  • 02Circadian rhythm and melatonin support anecdotally
  • 03Reported lifespan extension in rodent studies

§ 03   Dosing

Dosing protocol

Standard Protocol

Vial
10 mg
BAC Water
2 ml BAC water
Dose Range
5 – 10 mg per cycle, split daily
Starting Dose
5 mg/day for 10–20 days
Route
SubQ
Timing
PM
Frequency
Daily
Cycle
10–20 day courses, 1–2x per year

§ 04   Evidence

Evidence & research

Preclinical

Russian studies report telomerase and lifespan effects. Limited independent replication in Western labs.

FDA Status

Not FDA-approved.

§ 05   Stacks

Common stacks

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Restricted from compounding

Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.

Telehealth (Rx) · 1

Telehealth

Defy Medical

Rx required

Broadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.

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International · 5

International

Cosmic Nootropic

The most credible Russian / Khavinson source for US buyers. Sources authentic bioregulators through 'Peptides Company' (ex-NPCRIZ).

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International

Rupharma

12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.

Visit
International

Trident Peptides

1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.

1 flag on record
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International

Direct Peptides

Multi-region geo-routed mirrors. Multiple credible scam complaints. Documented customs seizures. Avoid absent stronger evidence.

2 flags on record
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International

Pharma Lab Global

Budget pricing but significant QC concerns. Claims HPLC+MS 'on request' not displayed.

1 flag on record
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Research-use-only · 6

Research-use-only

Swiss Chems

Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.

Third-Party Testing1 flag on record
Visit
Research-use-only

Limitless Life Nootropics

'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.

BBB Accredited +1
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Research-use-only

Core Peptides

Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.

Third-Party Testing1 flag on record
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Research-use-only

Ascension Peptides

Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.

Third-Party Testing
Visit
Research-use-only

Modern Aminos

Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.

Third-Party Testing
Visit
Research-use-only

Peptide Warehouse

US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.

Third-Party Testing1 flag on record
Visit

Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Rare; data limited

Contraindications

None specified.

This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.