§ 01 Overview
Overview
Anti-aging protein / hormone whose decline with age is implicated in multiple age-related diseases.
Strong animal and observational human data. No approved therapeutic form yet.
§ 02 Mechanism
Mechanism of action
Klotho exists as membrane and secreted forms. Secreted Klotho modulates FGF23 signaling, Wnt signaling, and insulin/IGF-1-like pathways, contributing to kidney health, cognition, and cardiovascular protection.
- 01Preclinical benefits for cognition, kidney, and CV health
- 02Candidate longevity biomarker
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Not characterized
- Route
- SubQ
- Frequency
- Research protocols vary
§ 04 Evidence
Evidence & research
Strong animal and observational human data. No approved therapeutic form yet.
FDA Status
Not FDA-approved. Research-only.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Anti-Aging Protein Research Takes a Step Forward with Cell Cloning - PR Newswire
Anti-Aging Protein Research Takes a Step Forward with Cell Cloning PR Newswire
A Key "Master" Protein That Declines by Half After Age 40. One Company Found a Way to Restore It. - PR Newswire
A Key "Master" Protein That Declines by Half After Age 40. One Company Found a Way to Restore It. PR Newswire
Klotho unveils AI-powered aging clock - Longevity.Technology
Klotho unveils AI-powered aging clock Longevity.Technology
Avaí Bio and Austrianova Begin Production of Master Cell Bank for Klotho Anti-Aging Therapy Under GMP Standards - PR Newswire
Avaí Bio and Austrianova Begin Production of Master Cell Bank for Klotho Anti-Aging Therapy Under GMP Standards PR Newswire
AI-powered Klotho Clock aims to read biological age from a blood test - Stock Titan
AI-powered Klotho Clock aims to read biological age from a blood test Stock Titan
Klotho Neurosciences (NASDAQ:KLTO) Initiates Development of the "Klotho Clock," a Diagnostic Biological Aging and Longevity Clock that Unlocks Health Testing Through Epigenetics and Artificial Intelligence (AI) - BioSpace
Klotho Neurosciences (NASDAQ:KLTO) Initiates Development of the "Klotho Clock," a Diagnostic Biological Aging and Longevity Clock that Unlocks Health Testing Through Epigenetics and Artificial Intelligence (AI) BioSpace
Klothea Bio Announces the Launch of a Phase 1b Clinical - GlobeNewswire
Klothea Bio Announces the Launch of a Phase 1b Clinical GlobeNewswire
Klotho Neurosciences Receives Patent Claims in Australia for Composition and Use of Human Secreted Klotho Protein ("s-KL") Isoform of the Human Klotho Gene Sequence - PR Newswire
Klotho Neurosciences Receives Patent Claims in Australia for Composition and Use of Human Secreted Klotho Protein ("s-KL") Isoform of the Human Klotho Gene Sequence PR Newswire
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
None specified.