§ 01 Overview
Overview
Anti-aging protein / hormone whose decline with age is implicated in multiple age-related diseases.
Strong animal and observational human data. No approved therapeutic form yet.
§ 02 Mechanism
Mechanism of action
Klotho exists as membrane and secreted forms. Secreted Klotho modulates FGF23 signaling, Wnt signaling, and insulin/IGF-1-like pathways, contributing to kidney health, cognition, and cardiovascular protection.
- 01Preclinical benefits for cognition, kidney, and CV health
- 02Candidate longevity biomarker
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Not characterized
- Route
- SubQ
- Frequency
- Research protocols vary
§ 04 Evidence
Evidence & research
Strong animal and observational human data. No approved therapeutic form yet.
FDA Status
Not FDA-approved. Research-only.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Avaí Bio and Austrianova Successfully Encapsulate - GlobeNewswire
Avaí Bio and Austrianova Successfully Encapsulate GlobeNewswire
Natural compound from medicinal herbs may slow kidney aging in diabetes by “un-silencing” an anti-aging gene - EurekAlert!
Natural compound from medicinal herbs may slow kidney aging in diabetes by “un-silencing” an anti-aging gene EurekAlert!
The Longevity World Is Obsessed With This Protein—and You Might Have a Genetic Variant That Boosts It - Robb Report
The Longevity World Is Obsessed With This Protein—and You Might Have a Genetic Variant That Boosts It Robb Report
Biotech Division of Greenland Mines Announces Issuance of Patent in Canada for the Klotho Gene Therapy Platform Technology for Alzheimer’s and Aging - InvestorNews
Biotech Division of Greenland Mines Announces Issuance of Patent in Canada for the Klotho Gene Therapy Platform Technology for Alzheimer’s and Aging InvestorNews
Greenland Mines Ltd Announces Australian Patent Grant for Klotho-Based Gene Therapy for Neuromuscular Diseases - Quiver Quantitative
Greenland Mines Ltd Announces Australian Patent Grant for Klotho-Based Gene Therapy for Neuromuscular Diseases Quiver Quantitative
Biotech Division of Greenland Mines Announces Australian Patent Grant for Klotho Gene Therapy Technology for Treatment of Neuromuscular Diseases - InvestorNews
Biotech Division of Greenland Mines Announces Australian Patent Grant for Klotho Gene Therapy Technology for Treatment of Neuromuscular Diseases InvestorNews
The Longevity Protein Race Reaches Manufacturing: One Microcap Just Completed A GMP Master Cell Bank For Its Anti-Aging Klotho Therapy - PR Newswire Canada
The Longevity Protein Race Reaches Manufacturing: One Microcap Just Completed A GMP Master Cell Bank For Its Anti-Aging Klotho Therapy PR Newswire Canada
Unapproved gene therapy for boosting longevity is set to go on sale - New Scientist
Unapproved gene therapy for boosting longevity is set to go on sale New Scientist
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
None specified.
§ 10 Questions
Klotho FAQ
- What is Klotho?
- Anti-aging protein / hormone whose decline with age is implicated in multiple age-related diseases. Klotho exists as membrane and secreted forms. Secreted Klotho modulates FGF23 signaling, Wnt signaling, and insulin/IGF-1-like pathways, contributing to kidney health, cognition, and cardiovascular protection.
- What is Klotho used for?
- Reported uses include preclinical benefits for cognition, kidney, and cv health and candidate longevity biomarker. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Klotho dosed?
- Commonly referenced dosing is Not characterized, typically research protocols vary, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Klotho?
- Commonly reported side effects include unknown in humans. This list is not exhaustive.
- Is Klotho legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved. Research-only..