§ 01 Overview
Overview
Anti-aging protein / hormone whose decline with age is implicated in multiple age-related diseases.
Strong animal and observational human data. No approved therapeutic form yet.
§ 02 Mechanism
Mechanism of action
Klotho exists as membrane and secreted forms. Secreted Klotho modulates FGF23 signaling, Wnt signaling, and insulin/IGF-1-like pathways, contributing to kidney health, cognition, and cardiovascular protection.
- 01Preclinical benefits for cognition, kidney, and CV health
- 02Candidate longevity biomarker
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Not characterized
- Route
- SubQ
- Frequency
- Research protocols vary
§ 04 Evidence
Evidence & research
Strong animal and observational human data. No approved therapeutic form yet.
FDA Status
Not FDA-approved. Research-only.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Avaí Bio and Austrianova Complete GMP Master Cell Bank, Begin Viral Testing for Cell-Based Klotho Anti-Aging Therapy - Morningstar
Avaí Bio and Austrianova Complete GMP Master Cell Bank, Begin Viral Testing for Cell-Based Klotho Anti-Aging Therapy Morningstar
Low magnesium may quietly push the body toward faster aging - Earth.com
Low magnesium may quietly push the body toward faster aging Earth.com
Anti-Aging Protein Research Takes a Step Forward with Cell Cloning - Newswire Canada
Anti-Aging Protein Research Takes a Step Forward with Cell Cloning Newswire Canada
Avaí Bio and Austrianova Begin Production of Master Cell Bank for Klotho Anti-Aging Therapy Under GMP Standards - PR Newswire
Avaí Bio and Austrianova Begin Production of Master Cell Bank for Klotho Anti-Aging Therapy Under GMP Standards PR Newswire
Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification - Nature
Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification Nature
Avant Technologies and Austrianova Advancing α-Klotho Cell Therapy as Mayo Clinic Study Links Low α-Klotho Levels to Poor Cardiovascular Survival - BioSpace
Avant Technologies and Austrianova Advancing α-Klotho Cell Therapy as Mayo Clinic Study Links Low α-Klotho Levels to Poor Cardiovascular Survival BioSpace
Klotho in diabetes mellitus: research progress and clinical implications - Frontiers
Klotho in diabetes mellitus: research progress and clinical implications Frontiers
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine - Nature
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine Nature
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
None specified.