§ 01 Overview
Overview
Synthetic peptide that selectively induces apoptosis in senescent cells by disrupting FOXO4–p53 interaction.
Mouse data from the Demaria lab. No human trials.
§ 02 Mechanism
Mechanism of action
FOXO4-DRI is a D-amino-acid retro-inverso peptide that binds FOXO4 and displaces p53, triggering p53-mediated apoptosis preferentially in senescent cells where FOXO4 is upregulated.
- 01Senolytic clearance of senescent cells (preclinical)
- 02Rejuvenation markers in aged mice
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Not characterized in humans
- Route
- SubQ
- Frequency
- Intermittent (hit-and-run senolytic protocols)
§ 04 Evidence
Evidence & research
Mouse data from the Demaria lab. No human trials.
FDA Status
Not FDA-approved.
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
None specified.
§ 10 Questions
FOXO4-DRI FAQ
- What is FOXO4-DRI?
- Synthetic peptide that selectively induces apoptosis in senescent cells by disrupting FOXO4–p53 interaction. FOXO4-DRI is a D-amino-acid retro-inverso peptide that binds FOXO4 and displaces p53, triggering p53-mediated apoptosis preferentially in senescent cells where FOXO4 is upregulated.
- What is FOXO4-DRI used for?
- Reported uses include senolytic clearance of senescent cells (preclinical) and rejuvenation markers in aged mice. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is FOXO4-DRI dosed?
- Commonly referenced dosing is Not characterized in humans, typically intermittent (hit-and-run senolytic protocols), administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of FOXO4-DRI?
- Commonly reported side effects include unknown in humans. This list is not exhaustive.
- Is FOXO4-DRI legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved..