§ 01 Overview
Overview
Thymic peptide that enhances T-cell maturation and innate immune function; approved in several countries for hepatitis and as an adjuvant.
Approved in 35+ countries. Multiple Phase II/III trials for HCV and as an adjuvant.
§ 02 Mechanism
Mechanism of action
Thymosin Alpha-1 activates TLR-2 and TLR-9 on immune cells, supports dendritic cell maturation, and enhances Th1 responses. It also upregulates IL-2 receptor expression on T cells.
- 01Immune modulation in chronic infection
- 02Adjuvant for vaccines and oncology in some countries
- 03Reduced severity of certain viral illnesses in trials
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 1.6 mg or 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 1.6 – 6 mg weekly (split)
- Starting Dose
- 1.6 mg SubQ 2x/week
- Route
- SubQ
- Timing
- AM
- Frequency
- 2x weekly
- Cycle
- 8–12 weeks
§ 04 Evidence
Evidence & research
Approved in 35+ countries. Multiple Phase II/III trials for HCV and as an adjuvant.
FDA Status
Not FDA-approved. Previously compounded; restricted under recent FDA guidance.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
The Precision Peptide Company Locks In Exclusive Manufacturing Rights Across Its Needle-Free Line - The Globe and Mail
The Precision Peptide Company Locks In Exclusive Manufacturing Rights Across Its Needle-Free Line The Globe and Mail
Complexes of an Alpha Thymosin Derivative with... : Chemical Biology and Drug Design - Ovid
Complexes of an Alpha Thymosin Derivative with... : Chemical Biology and Drug Design Ovid
what are the new weight loss drugs called - Meteo.gr
what are the new weight loss drugs called Meteo.gr
Thymosin Alpha-1: Immune Signaling and Molecular Research - Herald-Whig
Thymosin Alpha-1: Immune Signaling and Molecular Research Herald-Whig
RETRANSMISSION: The Precision Peptide Company Orders 20,000 Thymosin Alpha-1 Patches for Commercial Launch - Yahoo Finance
RETRANSMISSION: The Precision Peptide Company Orders 20,000 Thymosin Alpha-1 Patches for Commercial Launch Yahoo Finance
Precision Peptide orders 20,000 Thymosin Alpha-1 patches for launch - StreetInsider
Precision Peptide orders 20,000 Thymosin Alpha-1 patches for launch StreetInsider
The Precision Peptide Company Orders 20,000 Thymosin Alpha-1 Transdermal Patches for Commercial Launch - kalkine.ca
The Precision Peptide Company Orders 20,000 Thymosin Alpha-1 Transdermal Patches for Commercial Launch kalkine.ca
Out-of-pocket hospital costs reach 750 billion won in September 2025 - Korea JoongAng Daily
Out-of-pocket hospital costs reach 750 billion won in September 2025 Korea JoongAng Daily
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Telehealth (Rx) · 1
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
International · 2
Cosmic Nootropic
The most credible Russian / Khavinson source for US buyers. Sources authentic bioregulators through 'Peptides Company' (ex-NPCRIZ).
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Research-use-only · 1
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Injection site irritation
- 02Mild flu-like symptoms
Contraindications
None specified.
§ 10 Questions
Thymosin Alpha-1 FAQ
- What is Thymosin Alpha-1?
- Thymic peptide that enhances T-cell maturation and innate immune function; approved in several countries for hepatitis and as an adjuvant. Thymosin Alpha-1 activates TLR-2 and TLR-9 on immune cells, supports dendritic cell maturation, and enhances Th1 responses. It also upregulates IL-2 receptor expression on T cells.
- What is Thymosin Alpha-1 used for?
- Reported uses include immune modulation in chronic infection, adjuvant for vaccines and oncology in some countries, and reduced severity of certain viral illnesses in trials. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Thymosin Alpha-1 dosed?
- Commonly referenced dosing is 1.6 – 6 mg weekly (split), typically 2x weekly, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute Thymosin Alpha-1?
- For Thymosin Alpha-1, vials commonly come in 1.6 mg or 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of Thymosin Alpha-1?
- Commonly reported side effects include injection site irritation and mild flu-like symptoms. This list is not exhaustive.
- Is Thymosin Alpha-1 legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. Previously compounded; restricted under recent FDA guidance..