§ 01 Overview
Overview
The core GHK tripeptide without bound copper; lower potency than GHK-Cu but simpler formulation.
Weaker preclinical profile than GHK-Cu.
§ 02 Mechanism
Mechanism of action
GHK is a copper-binding tripeptide. Without copper, GHK retains some signaling activity but the characteristic tissue regeneration and gene-expression effects require Cu2+ binding for full potency.
- 01Milder skin and hair support vs. GHK-Cu
- 02Lower risk of copper overload
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Formulation-dependent
- Route
- Topical
- Frequency
- Daily
§ 04 Evidence
Evidence & research
Weaker preclinical profile than GHK-Cu.
FDA Status
Cosmetic ingredient.
§ 05 Stacks
Common stacks
§ 06 News
In the news
1 article from the last 12 months · updates hourly
Pal‑GHK: A Synthetic Peptide’s Potential in Research Implications - Fontana Herald News
Pal‑GHK: A Synthetic Peptide’s Potential in Research Implications Fontana Herald News
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Rare topical irritation
Contraindications
None specified.
§ 10 Questions
GHK (non-copper) FAQ
- What is GHK (non-copper)?
- The core GHK tripeptide without bound copper; lower potency than GHK-Cu but simpler formulation. GHK is a copper-binding tripeptide. Without copper, GHK retains some signaling activity but the characteristic tissue regeneration and gene-expression effects require Cu2+ binding for full potency.
- What is GHK (non-copper) used for?
- Reported uses include milder skin and hair support vs. ghk-cu and lower risk of copper overload. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is GHK (non-copper) dosed?
- Commonly referenced dosing is Formulation-dependent, typically daily, administered Topical. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of GHK (non-copper)?
- Commonly reported side effects include rare topical irritation. This list is not exhaustive.
- Is GHK (non-copper) legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Cosmetic ingredient..