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Peptide.Guide
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Snap-8

Acetyl Octapeptide-3

Topical peptide marketed as a 'Botox-like' muscle relaxant by modulating SNARE-complex assembly, reducing expression lines.

Read dosing protocol

§ 01   Overview

Overview

Topical peptide marketed as a 'Botox-like' muscle relaxant by modulating SNARE-complex assembly, reducing expression lines.

Cosmetic literature supports modest topical effects. No rigorous RCTs.

§ 02   Mechanism

Mechanism of action

Snap-8 mimics part of the SNAP-25 protein, competing for a place in the SNARE complex that drives neurotransmitter release at the neuromuscular junction. This is claimed to reduce muscle contraction and expression lines when applied topically.

  • 01Topical reduction of expression lines
  • 02Non-invasive alternative to neurotoxins

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
Formulation-dependent (typical 3–10%)
Route
Topical
Frequency
Daily
Cycle
12+ weeks to observe

§ 04   Evidence

Evidence & research

Preclinical

Cosmetic literature supports modest topical effects. No rigorous RCTs.

FDA Status

Cosmetic ingredient. Not a drug.

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Available as dietary supplement

Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

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§ 09   Safety

Safety & side effects

Side effects

  • 01Contact irritation rare

Contraindications

None specified.

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