§ 01 Overview
Overview
Lipidated procollagen-I fragment that feedback-stimulates fibroblast collagen/fibronectin synthesis. Reduces wrinkle depth in blinded trials.
Robinson 2005 topical RCT; Katayama 1993 collagen biology.
§ 02 Mechanism
Mechanism of action
Matrixyl is the procollagen-I C-terminus (KTTKS) lipidated with palmitic acid to cross the stratum corneum. It signals the fibroblast via the same feedback loop that procollagen fragments naturally use.
- 01Reduced wrinkle depth in double-blind topical trial
- 02Stimulates collagen I/IV, elastin, fibronectin
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Formulation-dependent (typical 3–5%)
- Route
- Topical
- Frequency
- 1–2x daily
- Cycle
- 12+ weeks to observe
§ 04 Evidence
Evidence & research
Robinson 2005 topical RCT; Katayama 1993 collagen biology.
FDA Status
Cosmetic ingredient; not a drug.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Reviewers in Their 60s Are Starting to Look 15 Years Younger Thanks to This One Anti-Aging Ingredient - Real Simple
Reviewers in Their 60s Are Starting to Look 15 Years Younger Thanks to This One Anti-Aging Ingredient Real Simple
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. - AOL.com
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. AOL.com
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. - Women's Health
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. Women's Health
Argireline Serums Are Growing in Popularity for Their "Botox-Like" Effects — These Are Our 10 Favorites - People.com
Argireline Serums Are Growing in Popularity for Their "Botox-Like" Effects — These Are Our 10 Favorites People.com
NEW No7 Protect & Perfect ADVANCED Anti-Ageing Sun Protection - Boots. With you, for life.
NEW No7 Protect & Perfect ADVANCED Anti-Ageing Sun Protection Boots. With you, for life.
This peptide serum is my best gate-kept secret for smooth skin - Glamour UK
This peptide serum is my best gate-kept secret for smooth skin Glamour UK
Olay Regenerist vs e.l.f Holy Hydration - Mamabella
Olay Regenerist vs e.l.f Holy Hydration Mamabella
68-Year-Olds Are Passing for 47 Thanks to This ‘Holy Grail’ Matrixyl Serum That Keeps Beauty Fans ‘Botox Free’ - Real Simple
68-Year-Olds Are Passing for 47 Thanks to This ‘Holy Grail’ Matrixyl Serum That Keeps Beauty Fans ‘Botox Free’ Real Simple
§ 07 Sourcing
Sourcing & supply
Regulatory status
Available as dietary supplement
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Rare contact irritation
Contraindications
None specified.
§ 10 Questions
Matrixyl (Palmitoyl Pentapeptide-4) FAQ
- What is Matrixyl (Palmitoyl Pentapeptide-4)?
- Lipidated procollagen-I fragment that feedback-stimulates fibroblast collagen/fibronectin synthesis. Reduces wrinkle depth in blinded trials. Matrixyl is the procollagen-I C-terminus (KTTKS) lipidated with palmitic acid to cross the stratum corneum. It signals the fibroblast via the same feedback loop that procollagen fragments naturally use.
- What is Matrixyl (Palmitoyl Pentapeptide-4) used for?
- Reported uses include reduced wrinkle depth in double-blind topical trial and stimulates collagen i/iv, elastin, fibronectin. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Matrixyl (Palmitoyl Pentapeptide-4) dosed?
- Commonly referenced dosing is Formulation-dependent ( 3–5%), typically 1–2x daily, administered Topical. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Matrixyl (Palmitoyl Pentapeptide-4)?
- Commonly reported side effects include rare contact irritation. This list is not exhaustive.
- Is Matrixyl (Palmitoyl Pentapeptide-4) legal?
- Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Cosmetic ingredient; not a drug..
§ 11 References
Selected references
- 01
Robinson — topical RCT
PMID: 18492178
- 02
Katayama — KTTKS biology
PMID: 8226859