§ 01 Overview
Overview
Lipidated procollagen-I fragment that feedback-stimulates fibroblast collagen/fibronectin synthesis. Reduces wrinkle depth in blinded trials.
Robinson 2005 topical RCT; Katayama 1993 collagen biology.
§ 02 Mechanism
Mechanism of action
Matrixyl is the procollagen-I C-terminus (KTTKS) lipidated with palmitic acid to cross the stratum corneum. It signals the fibroblast via the same feedback loop that procollagen fragments naturally use.
- 01Reduced wrinkle depth in double-blind topical trial
- 02Stimulates collagen I/IV, elastin, fibronectin
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Formulation-dependent (typical 3–5%)
- Route
- Topical
- Frequency
- 1–2x daily
- Cycle
- 12+ weeks to observe
§ 04 Evidence
Evidence & research
Robinson 2005 topical RCT; Katayama 1993 collagen biology.
FDA Status
Cosmetic ingredient; not a drug.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
The $17 Serum That Shoppers Call “Botox in a Bottle” Is Making 70-Year-Old Fans “Look 15 Years Younger” - Real Simple
The $17 Serum That Shoppers Call “Botox in a Bottle” Is Making 70-Year-Old Fans “Look 15 Years Younger” Real Simple
'Luscious' £55 cream for 'tightening ageing necks' now £32 - Birmingham Live
'Luscious' £55 cream for 'tightening ageing necks' now £32 Birmingham Live
Women 'feel confident with aging neck' with £20 off cream - Yorkshire Live
Women 'feel confident with aging neck' with £20 off cream Yorkshire Live
Byoma Longevit-8 Peptide Serum: Everything You Need to Know - BeautyNewsDaily
Byoma Longevit-8 Peptide Serum: Everything You Need to Know BeautyNewsDaily
Reviewers in Their 60s Are Starting to Look 15 Years Younger Thanks to This One Anti-Aging Ingredient - Real Simple
Reviewers in Their 60s Are Starting to Look 15 Years Younger Thanks to This One Anti-Aging Ingredient Real Simple
These Under-$30 Amazon Skin Care Products Work as Well as Luxury Anti-Aging Picks, According to Dermatologists - Real Simple
These Under-$30 Amazon Skin Care Products Work as Well as Luxury Anti-Aging Picks, According to Dermatologists Real Simple
The Best Peptide Serums That Smooth And Firm Skin - Forbes
The Best Peptide Serums That Smooth And Firm Skin Forbes
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. - Women's Health
This Topical Peptide Has Decades of Research Proving It Can Firm and Plump Skin. Here’s How to Use It. Women's Health
§ 07 Sourcing
Sourcing & supply
Regulatory status
Available as dietary supplement
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Rare contact irritation
Contraindications
None specified.
§ 10 Questions
Matrixyl (Palmitoyl Pentapeptide-4) FAQ
- What is Matrixyl (Palmitoyl Pentapeptide-4)?
- Lipidated procollagen-I fragment that feedback-stimulates fibroblast collagen/fibronectin synthesis. Reduces wrinkle depth in blinded trials. Matrixyl is the procollagen-I C-terminus (KTTKS) lipidated with palmitic acid to cross the stratum corneum. It signals the fibroblast via the same feedback loop that procollagen fragments naturally use.
- What is Matrixyl (Palmitoyl Pentapeptide-4) used for?
- Reported uses include reduced wrinkle depth in double-blind topical trial and stimulates collagen i/iv, elastin, fibronectin. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Matrixyl (Palmitoyl Pentapeptide-4) dosed?
- Commonly referenced dosing is Formulation-dependent ( 3–5%), typically 1–2x daily, administered Topical. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Matrixyl (Palmitoyl Pentapeptide-4)?
- Commonly reported side effects include rare contact irritation. This list is not exhaustive.
- Is Matrixyl (Palmitoyl Pentapeptide-4) legal?
- Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Cosmetic ingredient; not a drug..
§ 11 References
Selected references
- 01
Robinson — topical RCT
PMID: 18492178
- 02
Katayama — KTTKS biology
PMID: 8226859