§ 01 Overview
Overview
FDA-approved GHRH analog that specifically reduces visceral adipose tissue (VAT), originally developed for HIV-associated lipodystrophy.
FDA-approved 2010 for HIV-associated lipodystrophy. Extensive Phase III data; off-label use for VAT reduction.
§ 02 Mechanism
Mechanism of action
Tesamorelin is a stabilized GHRH(1-44) analog. It stimulates endogenous GH release and preferentially reduces visceral fat, with favorable effects on IGF-1 and hepatic fat.
- 01Targeted visceral fat reduction (15–20% VAT decrease)
- 02Improved liver fat markers
- 03Lean mass preservation
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 1 mg or 2 mg
- BAC Water
- 1 ml BAC water per vial
- Dose Range
- 1 – 2 mg daily
- Starting Dose
- 1 mg daily
- Route
- SubQ
- Timing
- Before bed
- Frequency
- Daily
- Cycle
- 12–26 weeks; reassess IGF-1
§ 04 Evidence
Evidence & research
FDA-approved 2010 for HIV-associated lipodystrophy. Extensive Phase III data; off-label use for VAT reduction.
FDA Status
FDA-approved (HIV lipodystrophy).
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
How to Buy Tesamorelin Peptide in 2026: What Research Buyers Should Check Before Ordering - inkl
How to Buy Tesamorelin Peptide in 2026: What Research Buyers Should Check Before Ordering inkl
Buy Tesamorelin Peptide: 5 Research Suppliers Compared for Quality, Testing & Price - Out South Florida
Buy Tesamorelin Peptide: 5 Research Suppliers Compared for Quality, Testing & Price Out South Florida
FDA Advisory No.2026-1263 || Public Health Warning Against the Purchase and Use of the Unregistered Drug Product “Tesamorelin 10 mg (Tesamorelin acetate, GHRH analog) Lyophilized Powder for Injection for Subcutaneous Use Only and Bacteriostatic W - fda.gov.ph
FDA Advisory No.2026-1263 || Public Health Warning Against the Purchase and Use of the Unregistered Drug Product “Tesamorelin 10 mg (Tesamorelin acetate, GHRH analog) Lyophilized Powder for Injection for Subcutaneous Use Only and Bacteriostatic W fda.gov.ph
NEOLISE Sculpt Review 2026: Could This Tesamorelin Program Be the Body-Recomposition Option GLP-1 Users are Looking Into Next? - Newswire
NEOLISE Sculpt Review 2026: Could This Tesamorelin Program Be the Body-Recomposition Option GLP-1 Users are Looking Into Next? Newswire
Tesamorelin Peptide Research: Inside a Fast-Growing Corner of the GHRH Analog Market - Yonkers Times
Tesamorelin Peptide Research: Inside a Fast-Growing Corner of the GHRH Analog Market Yonkers Times
Synthetic Growth Hormone-Releasing Peptides and the Rising Research Interest in Tesamorelin - dailynews.lk
Synthetic Growth Hormone-Releasing Peptides and the Rising Research Interest in Tesamorelin dailynews.lk
Tesamorelin GH Axis and current research - YouTube
Tesamorelin GH Axis and current research YouTube
Tesamorelin Explained: The FDA-Approved GHRH Analog That Sits in a Unique Position in Peptide Research - Haute Living
Tesamorelin Explained: The FDA-Approved GHRH Analog That Sits in a Unique Position in Peptide Research Haute Living
§ 07 Sourcing
Sourcing & supply
Regulatory status
FDA-approved
This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status.
503B pharmacies · 5
Empower Pharmacy
Rx requiredOne of the largest US compounders by volume; dual 503A + 503B. Repeat FDA enforcement history and ongoing Lilly litigation.
Olympia Pharmaceuticals
Rx required35+ year family-owned dual 503A/503B licensed in 48–49 states. Among the cleanest mid-sized 503Bs operating today.
Belmar Pharma Solutions
Rx requiredWebster Equity portfolio. Triple-credentialed (PCAB + NABP + LegitScript), licensed in all 50 states. Among the most credentialed operators.
Fagron Sterile Services
Rx requiredEstablished 503B outsourcing facility in FDA's registered list.
Wedgewood Connect
Rx requiredFDA-registered 503B outsourcing facility.
Telehealth (Rx) · 1
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Research-use-only · 3
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Injection site erythema
- 02Arthralgia
- 03Elevated IGF-1
Contraindications
- 01Active malignancy
- 02Pituitary disorders
§ 10 Questions
Tesamorelin FAQ
- What is Tesamorelin?
- FDA-approved GHRH analog that specifically reduces visceral adipose tissue (VAT), originally developed for HIV-associated lipodystrophy. Tesamorelin is a stabilized GHRH(1-44) analog. It stimulates endogenous GH release and preferentially reduces visceral fat, with favorable effects on IGF-1 and hepatic fat.
- What is Tesamorelin used for?
- Reported uses include targeted visceral fat reduction (15–20% vat decrease), improved liver fat markers, and lean mass preservation. Evidence strength is rated Established — see the evidence section for detail.
- How is Tesamorelin dosed?
- Commonly referenced dosing is 1 – 2 mg daily, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute Tesamorelin?
- For Tesamorelin, vials commonly come in 1 mg or 2 mg and a common reconstitution is 1 ml BAC water per vial. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of Tesamorelin?
- Commonly reported side effects include injection site erythema, arthralgia, and elevated igf-1. This list is not exhaustive.
- Is Tesamorelin legal?
- This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status. FDA status: FDA-approved (HIV lipodystrophy)..