§ 01 Overview
Overview
Selective ghrelin receptor agonist that releases GH without meaningfully raising cortisol or prolactin. The cleanest GHRP.
Strong preclinical pharmacology and small early human trials. Widely used in clinical research and compounding. No late-stage FDA trials.
§ 02 Mechanism
Mechanism of action
Ipamorelin is a pentapeptide GH-releasing peptide (GHRP) that selectively stimulates the ghrelin/GHS-R1a receptor on pituitary somatotrophs. Unlike GHRP-2/6, it has minimal effect on cortisol, ACTH, or prolactin release.
- 01Pulsatile GH release that mimics physiological patterns
- 02Improved sleep depth and recovery
- 03Body composition support when paired with CJC-1295
- 04Minimal side-effect profile
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 300 mcg per dose
- Starting Dose
- 200 mcg
- Route
- SubQ
- Timing
- Before bed on empty stomach, optional AM dose
- Frequency
- Daily (1–3x/day)
- Cycle
- 8–12 weeks on, 4 weeks off
Storage
Refrigerate reconstituted vial; stable ~30 days at 4°C.
§ 04 Evidence
Evidence & research
Strong preclinical pharmacology and small early human trials. Widely used in clinical research and compounding. No late-stage FDA trials.
FDA Status
Not FDA-approved. Historically compounded; compounding restricted under 2023 FDA guidance on bulk peptides.
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
where do you get glutathione Ipamorelin ,un peptide che rilascia l'ormone della crescita (GHRP) - FISM TV
where do you get glutathione Ipamorelin ,un peptide che rilascia l'ormone della crescita (GHRP) FISM TV
UFC Suspends Bassil Hafez for One Year Over Ipamorelin Doping - BVM Sports
UFC Suspends Bassil Hafez for One Year Over Ipamorelin Doping BVM Sports
Umbrella Lab Announces Documentation And Traceability Update For Ipamorelin Peptide - GlobeNewswire
Umbrella Lab Announces Documentation And Traceability Update For Ipamorelin Peptide GlobeNewswire
Decoding the peptide craze: UAE experts explain the risky injectable wellness trend and what science says - Gulf News
Decoding the peptide craze: UAE experts explain the risky injectable wellness trend and what science says Gulf News
Can Ipamorelin cause erectile dysfunction? - Portal CNJ
Can Ipamorelin cause erectile dysfunction? Portal CNJ
CJC-1295 Ipamorelin Erectile Dysfunction: What the Evidence Shows - Portal CNJ
CJC-1295 Ipamorelin Erectile Dysfunction: What the Evidence Shows Portal CNJ
CJC 1295 Ipamorelin Erectile Dysfunction: What the Evidence and Experience Show - Portal CNJ
CJC 1295 Ipamorelin Erectile Dysfunction: What the Evidence and Experience Show Portal CNJ
The peptide problem: Hype is outrunning the evidence - The Conversation
The peptide problem: Hype is outrunning the evidence The Conversation
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
503B pharmacies · 2
Belmar Pharma Solutions
Rx requiredWebster Equity portfolio. Triple-credentialed (PCAB + NABP + LegitScript), licensed in all 50 states. Among the most credentialed operators.
Hallandale Pharmacy (Pharmcore)
Rx required503A with historic warning letter (2020, closed out 2022). Major telehealth fulfillment partner.
Telehealth (Rx) · 3
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Marek Health
Rx requiredPremium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.
Blokes / Joi Women's Wellness
Rx requiredMen's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.
International · 3
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Direct Peptides
Multi-region geo-routed mirrors. Multiple credible scam complaints. Documented customs seizures. Avoid absent stronger evidence.
Canlab
Health Canada public warning December 2023. Operates across mirror domains to evade takedowns. Avoid.
Research-use-only · 7
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Ascension Peptides
Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.
Modern Aminos
Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.
Peptide Warehouse
US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.
BioTech Peptides
Claims >99% purity via HPLC + MS. Accepts cards and PayPal. 30-day money-back.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Transient flushing or tingling
- 02Mild water retention
- 03Hunger pangs (ghrelin activity)
Contraindications
None specified.