§ 01 Overview
Overview
Short-acting GHRH analog that amplifies natural GH pulses. Almost always paired with a GHRP like Ipamorelin.
Human PK studies exist; clinical outcome trials are limited. Widely used in research and compounding contexts.
§ 02 Mechanism
Mechanism of action
CJC-1295 without DAC is a tetrasubstituted GHRH(1-29) analog. It binds the GHRH receptor on the pituitary to amplify pulsatile GH release. Half-life is ~30 minutes, preserving natural pulsatility (vs. the DAC version which flattens pulses).
- 01Synergizes with GHRPs to amplify GH pulses
- 02Preserves physiological pulsatility
- 03Supports recovery, sleep, and body composition
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 300 mcg per dose
- Starting Dose
- 100 mcg with 100 mcg Ipamorelin
- Route
- SubQ
- Timing
- Before bed, empty stomach
- Frequency
- Daily, 1–3x/day
- Cycle
- 8–12 weeks on, 4 off
§ 04 Evidence
Evidence & research
Human PK studies exist; clinical outcome trials are limited. Widely used in research and compounding contexts.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
1 article from the last 12 months · updates hourly
Scared of needles? What science says about the peptide nasal sprays on the rise - New York Post
Scared of needles? What science says about the peptide nasal sprays on the rise New York Post
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
503B pharmacies · 2
Belmar Pharma Solutions
Rx requiredWebster Equity portfolio. Triple-credentialed (PCAB + NABP + LegitScript), licensed in all 50 states. Among the most credentialed operators.
Hallandale Pharmacy (Pharmcore)
Rx required503A with historic warning letter (2020, closed out 2022). Major telehealth fulfillment partner.
Telehealth (Rx) · 3
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Marek Health
Rx requiredPremium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.
Blokes / Joi Women's Wellness
Rx requiredMen's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.
International · 3
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Direct Peptides
Multi-region geo-routed mirrors. Multiple credible scam complaints. Documented customs seizures. Avoid absent stronger evidence.
Canlab
Health Canada public warning December 2023. Operates across mirror domains to evade takedowns. Avoid.
Research-use-only · 7
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Ascension Peptides
Among newer RUO vendors with cleaner credibility signals. SafeCert Labs (CLIA-certified) testing, 4.8 Trustpilot. US-only.
Modern Aminos
Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.
Peptide Warehouse
US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.
BioTech Peptides
Claims >99% purity via HPLC + MS. Accepts cards and PayPal. 30-day money-back.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Injection site flushing
- 02Water retention at higher doses
Contraindications
None specified.
§ 10 Questions
CJC-1295 (No DAC) FAQ
- What is CJC-1295 (No DAC)?
- Short-acting GHRH analog that amplifies natural GH pulses. Almost always paired with a GHRP like Ipamorelin. CJC-1295 without DAC is a tetrasubstituted GHRH(1-29) analog. It binds the GHRH receptor on the pituitary to amplify pulsatile GH release. Half-life is ~30 minutes, preserving natural pulsatility (vs. the DAC version which flattens pulses).
- What is CJC-1295 (No DAC) used for?
- Reported uses include synergizes with ghrps to amplify gh pulses, preserves physiological pulsatility, and supports recovery, sleep, and body composition. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is CJC-1295 (No DAC) dosed?
- Commonly referenced dosing is 100 – 300 mcg per dose, typically daily, 1–3x/day, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute CJC-1295 (No DAC)?
- For CJC-1295 (No DAC), vials commonly come in 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of CJC-1295 (No DAC)?
- Commonly reported side effects include injection site flushing and water retention at higher doses. This list is not exhaustive.
- Is CJC-1295 (No DAC) legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved..