§ 01 Overview
Overview
Classic GHRH + GHRP combination that amplifies endogenous GH pulses more than either alone.
Widely used in research / compounding; no late-stage FDA outcome trials.
§ 02 Mechanism
Mechanism of action
Combines the short-acting GHRH analog CJC-1295 (no DAC) with the selective ghrelin receptor agonist Ipamorelin. The two act on different pituitary receptors and produce a larger GH pulse than either alone.
- 01Larger physiological GH pulses
- 02Improved recovery and sleep anecdotally
- 03Clean side-effect profile of Ipamorelin preserved
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg / 5 mg combo vial
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 300 mcg of each peptide
- Starting Dose
- 100 mcg CJC + 100 mcg Ipamorelin
- Route
- SubQ
- Timing
- Before bed or pre-workout, empty stomach
- Frequency
- 1–3x per day
- Cycle
- 8–12 weeks on, 4 off
§ 04 Evidence
Evidence & research
Widely used in research / compounding; no late-stage FDA outcome trials.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
6 articles from the last 12 months · updates hourly
RFK Jr.'s Peptide Plan Explained, Why Most Substances Already Cleared but Few Are Fully Approved - Sacramento Bee
RFK Jr.'s Peptide Plan Explained, Why Most Substances Already Cleared but Few Are Fully Approved Sacramento Bee
The Peptide Reclassification Everyone's Talking About: A Pharmacist's Take on What RFK Jr's Announcement Actually Means - Pharmacy Times
The Peptide Reclassification Everyone's Talking About: A Pharmacist's Take on What RFK Jr's Announcement Actually Means Pharmacy Times
The peptide problem: Hype is outrunning the evidence - The Conversation
The peptide problem: Hype is outrunning the evidence The Conversation
CJC 1295 Ipamorelin Unveiled 2026: Examining the Science - GlobeNewswire
CJC 1295 Ipamorelin Unveiled 2026: Examining the Science GlobeNewswire
Synergistic Horizons: Exploring CJC-1295, Ipamorelin, and GHRP-2 Peptide Blend - Media Hindustan
Synergistic Horizons: Exploring CJC-1295, Ipamorelin, and GHRP-2 Peptide Blend Media Hindustan
SynergenX Network Clinics Expand Peptide Therapy Options with BPC-157 and CJC-1295 + Ipamorelin - Business Wire
SynergenX Network Clinics Expand Peptide Therapy Options with BPC-157 and CJC-1295 + Ipamorelin Business Wire
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Telehealth (Rx) · 3
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Marek Health
Rx requiredPremium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.
Blokes / Joi Women's Wellness
Rx requiredMen's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.
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§ 09 Safety
Safety & side effects
Side effects
- 01Flushing, mild water retention
Contraindications
None specified.
§ 10 Questions
CJC-1295 + Ipamorelin FAQ
- What is CJC-1295 + Ipamorelin?
- Classic GHRH + GHRP combination that amplifies endogenous GH pulses more than either alone. Combines the short-acting GHRH analog CJC-1295 (no DAC) with the selective ghrelin receptor agonist Ipamorelin. The two act on different pituitary receptors and produce a larger GH pulse than either alone.
- What is CJC-1295 + Ipamorelin used for?
- Reported uses include larger physiological gh pulses, improved recovery and sleep anecdotally, and clean side-effect profile of ipamorelin preserved. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is CJC-1295 + Ipamorelin dosed?
- Commonly referenced dosing is 100 – 300 mcg of each peptide, typically 1–3x per day, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute CJC-1295 + Ipamorelin?
- For CJC-1295 + Ipamorelin, vials commonly come in 5 mg / 5 mg combo vial and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of CJC-1295 + Ipamorelin?
- Commonly reported side effects include flushing, mild water retention. This list is not exhaustive.
- Is CJC-1295 + Ipamorelin legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved..