§ 01 Overview
Overview
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that increases intracellular NAD+ and SAM and may reduce adiposity.
Strong mouse model data. No substantial human clinical trials published to date.
§ 02 Mechanism
Mechanism of action
5-Amino-1MQ inhibits NNMT, an enzyme overexpressed in white adipose tissue of obese subjects. Inhibition preserves methyl donors and NAD+, shifting adipocytes toward a leaner, more thermogenic phenotype in preclinical models.
- 01Preclinical reduction in adiposity
- 02Increased NAD+ and SAM availability
- 03Improved metabolic markers in animal studies
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 50 – 150 mg daily (anecdotal)
- Starting Dose
- 50 mg daily
- Route
- Oral
- Timing
- AM
- Frequency
- Daily
- Cycle
- 8 weeks on, 4 off
§ 04 Evidence
Evidence & research
Strong mouse model data. No substantial human clinical trials published to date.
FDA Status
Not FDA-approved. Sold as research chemical.
§ 06 News
In the news
7 articles from the last 12 months · updates hourly
5-amino-1mq peptide effects 5-Amino-1MQ Peptide: Benefits, Side Effects & How It Targets Fat Loss (2026) - news36live
5-amino-1mq peptide effects 5-Amino-1MQ Peptide: Benefits, Side Effects & How It Targets Fat Loss (2026) news36live
I bought peptides with crypto. How my purchase helped fuel a $100 million gray-market, ‘looksmaxxing’ economy - Fortune
I bought peptides with crypto. How my purchase helped fuel a $100 million gray-market, ‘looksmaxxing’ economy Fortune
5-amino-1mq 50mg vial Peptide 5-Amino-1MQ - Financial Issues Stewardship Ministries
5-amino-1mq 50mg vial Peptide 5-Amino-1MQ Financial Issues Stewardship Ministries
5-amino-1mq 10mg 5-Amino-1MQ 10mg - Financial Issues Stewardship Ministries
5-amino-1mq 10mg 5-Amino-1MQ 10mg Financial Issues Stewardship Ministries
5-amino-1mq 50mg reconstitution VITAMIN B12 (Generic) Injectable Solution, 1000-mcg/mL, 100-mL vial - Easy Refills - Financial Issues Stewardship Ministries
5-amino-1mq 50mg reconstitution VITAMIN B12 (Generic) Injectable Solution, 1000-mcg/mL, 100-mL vial - Easy Refills Financial Issues Stewardship Ministries
FDA Sends 30 Warning Letters To Continue Clampdown on Compounded GLP-1s - BioSpace
FDA Sends 30 Warning Letters To Continue Clampdown on Compounded GLP-1s BioSpace
Umbrella Labs Introduces Research Use Only 5 AMINO 1MQ Liquid Program To Support High Rigor NNMT, NAD+ Salvage, And Methyl Donor Bench Science - ACCESS Newswire
Umbrella Labs Introduces Research Use Only 5 AMINO 1MQ Liquid Program To Support High Rigor NNMT, NAD+ Salvage, And Methyl Donor Bench Science ACCESS Newswire
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
Research-use-only · 1
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Insufficient human safety data
- 02Possible methylation effects
Contraindications
None specified.
§ 10 Questions
5-Amino-1MQ FAQ
- What is 5-Amino-1MQ?
- Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that increases intracellular NAD+ and SAM and may reduce adiposity. 5-Amino-1MQ inhibits NNMT, an enzyme overexpressed in white adipose tissue of obese subjects. Inhibition preserves methyl donors and NAD+, shifting adipocytes toward a leaner, more thermogenic phenotype in preclinical models.
- What is 5-Amino-1MQ used for?
- Reported uses include preclinical reduction in adiposity, increased nad+ and sam availability, and improved metabolic markers in animal studies. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is 5-Amino-1MQ dosed?
- Commonly referenced dosing is 50 – 150 mg daily (anecdotal), administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of 5-Amino-1MQ?
- Commonly reported side effects include insufficient human safety data and possible methylation effects. This list is not exhaustive.
- Is 5-Amino-1MQ legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved. Sold as research chemical..