§ 01 Overview
Overview
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that increases intracellular NAD+ and SAM and may reduce adiposity.
Strong mouse model data. No substantial human clinical trials published to date.
§ 02 Mechanism
Mechanism of action
5-Amino-1MQ inhibits NNMT, an enzyme overexpressed in white adipose tissue of obese subjects. Inhibition preserves methyl donors and NAD+, shifting adipocytes toward a leaner, more thermogenic phenotype in preclinical models.
- 01Preclinical reduction in adiposity
- 02Increased NAD+ and SAM availability
- 03Improved metabolic markers in animal studies
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 50 – 150 mg daily (anecdotal)
- Starting Dose
- 50 mg daily
- Route
- Oral
- Timing
- AM
- Frequency
- Daily
- Cycle
- 8 weeks on, 4 off
§ 04 Evidence
Evidence & research
Strong mouse model data. No substantial human clinical trials published to date.
FDA Status
Not FDA-approved. Sold as research chemical.
§ 06 News
In the news
3 articles from the last 12 months · updates hourly
Peptides for Weight Loss Reviews 2026: 9 Months of Real Results, Side Effects, and Second Thoughts - CLGF
Peptides for Weight Loss Reviews 2026: 9 Months of Real Results, Side Effects, and Second Thoughts CLGF
FDA Sends 30 Warning Letters To Continue Clampdown on Compounded GLP-1s - BioSpace
FDA Sends 30 Warning Letters To Continue Clampdown on Compounded GLP-1s BioSpace
Umbrella Labs Introduces Research Use Only 5 AMINO 1MQ Liquid Program To Support High Rigor NNMT, NAD+ Salvage, And Methyl Donor Bench Science - Yahoo Finance
Umbrella Labs Introduces Research Use Only 5 AMINO 1MQ Liquid Program To Support High Rigor NNMT, NAD+ Salvage, And Methyl Donor Bench Science Yahoo Finance
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
Research-use-only · 1
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
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§ 09 Safety
Safety & side effects
Side effects
- 01Insufficient human safety data
- 02Possible methylation effects
Contraindications
None specified.