§ 01 Overview
Overview
PPARδ agonist that increases fatty-acid oxidation and endurance in preclinical models. Development halted over carcinogenicity findings in rats.
Development discontinued by GSK due to cancer signals in long-term rat studies. WADA-banned at all times.
§ 02 Mechanism
Mechanism of action
Cardarine activates PPARδ, a nuclear receptor that upregulates genes involved in fatty-acid oxidation, mitochondrial biogenesis, and endurance. It does not bind to any peptide receptor.
- 01Improved endurance in preclinical models
- 02Increased fatty-acid oxidation
- 03Lipid profile improvements in early human studies
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 10 – 20 mg daily (research)
- Route
- Oral
- Frequency
- Daily
- Cycle
- Short cycles 4–8 weeks at most
§ 04 Evidence
Evidence & research
Development discontinued by GSK due to cancer signals in long-term rat studies. WADA-banned at all times.
FDA Status
Not FDA-approved. WADA prohibited.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Edmonton Elks' Darien Newell suspended for 9 games after second doping violation - CBC
Edmonton Elks' Darien Newell suspended for 9 games after second doping violation CBC
How Multi-Peptide Blends Like KLOW Are Formulated - The Future of Things
How Multi-Peptide Blends Like KLOW Are Formulated The Future of Things
Risk of Pancreatic Cancer May Be Increased by Performance Enhances Like Cardarine - MedicalResearch.com
Risk of Pancreatic Cancer May Be Increased by Performance Enhances Like Cardarine MedicalResearch.com
Why the AIU handed NCAA champion Adaejah Hodge of Georgia a secret doping ban - LetsRun.com
Why the AIU handed NCAA champion Adaejah Hodge of Georgia a secret doping ban LetsRun.com
Hodge returns after ban as GW1516 pattern links her to Asinga and Coach Phiri - Queen Atletica
Hodge returns after ban as GW1516 pattern links her to Asinga and Coach Phiri Queen Atletica
NCAA sprint champion involved in elaborate doping scheme - Canadian Running Magazine
NCAA sprint champion involved in elaborate doping scheme Canadian Running Magazine
Aussie athletes awarded gold and bronze after rival runner disqualified and suspended - Yahoo News Australia
Aussie athletes awarded gold and bronze after rival runner disqualified and suspended Yahoo News Australia
Adaejah Hodge Served Doping Ban, AIU Announces Today - Yahoo Sports
Adaejah Hodge Served Doping Ban, AIU Announces Today Yahoo Sports
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Long-term carcinogenicity concern
- 02Unknown human safety profile
Contraindications
- 01Personal or family cancer history
- 02Pregnancy
§ 10 Questions
Cardarine FAQ
- What is Cardarine?
- PPARδ agonist that increases fatty-acid oxidation and endurance in preclinical models. Development halted over carcinogenicity findings in rats. Cardarine activates PPARδ, a nuclear receptor that upregulates genes involved in fatty-acid oxidation, mitochondrial biogenesis, and endurance. It does not bind to any peptide receptor.
- What is Cardarine used for?
- Reported uses include improved endurance in preclinical models, increased fatty-acid oxidation, and lipid profile improvements in early human studies. Evidence strength is rated Experimental — see the evidence section for detail.
- How is Cardarine dosed?
- Commonly referenced dosing is 10 – 20 mg daily (research), administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Cardarine?
- Commonly reported side effects include long-term carcinogenicity concern and unknown human safety profile. This list is not exhaustive.
- Is Cardarine legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved. WADA prohibited..