§ 01 Overview
Overview
Mitochondrial-derived peptide with cytoprotective effects across neurons, cardiomyocytes, and beta cells; a candidate longevity signaling peptide.
Strong preclinical data from Cohen lab and others. Early human biomarker studies; no late-stage trials.
§ 02 Mechanism
Mechanism of action
Humanin is a 24-amino-acid peptide encoded within mitochondrial 16S rRNA. It binds FPR2 and IL-6/CNTF-like receptors to activate STAT3 and protect cells from oxidative and apoptotic stress.
- 01Neuroprotection in Alzheimer's models
- 02Improved beta cell survival
- 03Cardioprotection in ischemia models
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 500 mcg – 2 mg (research)
- Route
- SubQ
- Frequency
- 3x per week
- Cycle
- 8 weeks
§ 04 Evidence
Evidence & research
Strong preclinical data from Cohen lab and others. Early human biomarker studies; no late-stage trials.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
4 articles from the last 12 months · updates hourly
Many peptides sound like Yiddish words. Here’s why. - Jewish Telegraphic Agency
Many peptides sound like Yiddish words. Here’s why. Jewish Telegraphic Agency
Why Are People Injecting Themselves with Peptides? - The New Yorker
Why Are People Injecting Themselves with Peptides? The New Yorker
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull - Nature
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull Nature
Mitochondrial peptides: A new frontier in research - vietnamnews.vn
Mitochondrial peptides: A new frontier in research vietnamnews.vn
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Insufficient human safety data
Contraindications
None specified.