§ 01 Overview
Overview
Mitochondrial-derived peptide with cytoprotective effects across neurons, cardiomyocytes, and beta cells; a candidate longevity signaling peptide.
Strong preclinical data from Cohen lab and others. Early human biomarker studies; no late-stage trials.
§ 02 Mechanism
Mechanism of action
Humanin is a 24-amino-acid peptide encoded within mitochondrial 16S rRNA. It binds FPR2 and IL-6/CNTF-like receptors to activate STAT3 and protect cells from oxidative and apoptotic stress.
- 01Neuroprotection in Alzheimer's models
- 02Improved beta cell survival
- 03Cardioprotection in ischemia models
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 500 mcg – 2 mg (research)
- Route
- SubQ
- Frequency
- 3x per week
- Cycle
- 8 weeks
§ 04 Evidence
Evidence & research
Strong preclinical data from Cohen lab and others. Early human biomarker studies; no late-stage trials.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
4 articles from the last 12 months · updates hourly
Humanin: A Mitochondrial Signal in Cellular Resilience - nigerianeye.com
Humanin: A Mitochondrial Signal in Cellular Resilience nigerianeye.com
Injections of ‘MOTS-c’ Can Make You Live Longer. If You Are a Mouse - McGill University
Injections of ‘MOTS-c’ Can Make You Live Longer. If You Are a Mouse McGill University
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull - Nature
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull Nature
Humanin Peptide: A Mitochondrial Signal with Broad Research Potential - The Stratford Observer
Humanin Peptide: A Mitochondrial Signal with Broad Research Potential The Stratford Observer
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Insufficient human safety data
Contraindications
None specified.
§ 10 Questions
Humanin FAQ
- What is Humanin?
- Mitochondrial-derived peptide with cytoprotective effects across neurons, cardiomyocytes, and beta cells; a candidate longevity signaling peptide. Humanin is a 24-amino-acid peptide encoded within mitochondrial 16S rRNA. It binds FPR2 and IL-6/CNTF-like receptors to activate STAT3 and protect cells from oxidative and apoptotic stress.
- What is Humanin used for?
- Reported uses include neuroprotection in alzheimer's models, improved beta cell survival, and cardioprotection in ischemia models. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Humanin dosed?
- Commonly referenced dosing is 500 mcg – 2 mg (research), typically 3x per week, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Humanin?
- Commonly reported side effects include insufficient human safety data. This list is not exhaustive.
- Is Humanin legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved..