§ 01 Overview
Overview
Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways.
Extensive preclinical literature. Human trials of NMN/NR show modest benefit. IV NAD+ lacks rigorous outcome trials.
§ 02 Mechanism
Mechanism of action
NAD+ is required for sirtuin, PARP, and CD38 activity. Cellular NAD+ declines with age. Restoring NAD+ or precursors (NMN/NR) is hypothesized to enhance mitochondrial function and DNA repair.
- 01Energy and cognition anecdotally
- 02Mitochondrial support
- 03Exploratory longevity interventions
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 50 – 250 mg SubQ or 250–1000 mg IV
- Route
- SubQ
- Frequency
- 2–5x weekly
- Cycle
- 4–8 weeks
§ 04 Evidence
Evidence & research
Extensive preclinical literature. Human trials of NMN/NR show modest benefit. IV NAD+ lacks rigorous outcome trials.
FDA Status
Not approved as a drug; marketed as supplement and IV therapy.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Arbonne Launches NAD+ Duo Built for the New Era of Proactive Longevity - PR Newswire
Arbonne Launches NAD+ Duo Built for the New Era of Proactive Longevity PR Newswire
GNC Launches MitoQ Pure and MitoQ NAD+ Dual Action in The Drop, by GNC, Expanding Access to Cellular Health Innovation - Morningstar
GNC Launches MitoQ Pure and MitoQ NAD+ Dual Action in The Drop, by GNC, Expanding Access to Cellular Health Innovation Morningstar
NAD+ supplements may fuel treatment-resistant cancer cells, researchers warn - Nutrition Insight
NAD+ supplements may fuel treatment-resistant cancer cells, researchers warn Nutrition Insight
NXT USA and Laila Nutra to showcase NAD+, joint health and women's hormonal ingredients at Vitafoods Europe - Nutraceutical Business Review
NXT USA and Laila Nutra to showcase NAD+, joint health and women's hormonal ingredients at Vitafoods Europe Nutraceutical Business Review
ReadyRx NAD+ Rx Claims Evaluated: 2026 Update Highlights Changes in Prescription NAD+ Nasal Spray and Injection Access, Pricing, and Telehealth Eligibility - Yahoo Finance
ReadyRx NAD+ Rx Claims Evaluated: 2026 Update Highlights Changes in Prescription NAD+ Nasal Spray and Injection Access, Pricing, and Telehealth Eligibility Yahoo Finance
Grant Industries, BCR Introduce Longevity Active Bakuchiol NAD+ BCR - Cosmetics & Toiletries
Grant Industries, BCR Introduce Longevity Active Bakuchiol NAD+ BCR Cosmetics & Toiletries
A Combination NAD+ Treatment Has Benefits for Mice - Lifespan Research Institute
A Combination NAD+ Treatment Has Benefits for Mice Lifespan Research Institute
Gwyneth Paltrow Dubs This Skin-Firming Moisturizer a “Holy Grail” for Plumping Fine Lines and Wrinkles - instyle.com
Gwyneth Paltrow Dubs This Skin-Firming Moisturizer a “Holy Grail” for Plumping Fine Lines and Wrinkles instyle.com
§ 07 Sourcing
Sourcing & supply
Regulatory status
Available as dietary supplement
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).
503B pharmacies · 4
Empower Pharmacy
Rx requiredOne of the largest US compounders by volume; dual 503A + 503B. Repeat FDA enforcement history and ongoing Lilly litigation.
Olympia Pharmaceuticals
Rx required35+ year family-owned dual 503A/503B licensed in 48–49 states. Among the cleanest mid-sized 503Bs operating today.
Belmar Pharma Solutions
Rx requiredWebster Equity portfolio. Triple-credentialed (PCAB + NABP + LegitScript), licensed in all 50 states. Among the most credentialed operators.
Fagron Sterile Services
Rx requiredEstablished 503B outsourcing facility in FDA's registered list.
Telehealth (Rx) · 4
Defy Medical
Rx requiredBroadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.
Ivim Health
Rx required~100 providers. Filed amicus brief supporting OFA's tirzepatide appeal. Joined Outsourcing Facilities Association.
Blokes / Joi Women's Wellness
Rx requiredMen's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.
Superpower
Rx requiredLongevity-biomarker subscription ($199/yr, 100+ biomarkers) with narrow prescription formulary.
Research-use-only · 1
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Flushing and chest pressure (IV)
- 02Nausea
- 03Injection site pain
Contraindications
None specified.