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PreclinicalMitochondrialSubQ2–5x weeklyPartial data

NAD+

Nicotinamide Adenine Dinucleotide

Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways.

Read dosing protocol

◆ Editorial note

Coenzyme, not a peptide. Often administered IV or SubQ.

§ 01   Overview

Overview

Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways.

Extensive preclinical literature. Human trials of NMN/NR show modest benefit. IV NAD+ lacks rigorous outcome trials.

§ 02   Mechanism

Mechanism of action

NAD+ is required for sirtuin, PARP, and CD38 activity. Cellular NAD+ declines with age. Restoring NAD+ or precursors (NMN/NR) is hypothesized to enhance mitochondrial function and DNA repair.

  • 01Energy and cognition anecdotally
  • 02Mitochondrial support
  • 03Exploratory longevity interventions

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
50 – 250 mg SubQ or 250–1000 mg IV
Route
SubQ
Frequency
2–5x weekly
Cycle
4–8 weeks

§ 04   Evidence

Evidence & research

Preclinical

Extensive preclinical literature. Human trials of NMN/NR show modest benefit. IV NAD+ lacks rigorous outcome trials.

FDA Status

Not approved as a drug; marketed as supplement and IV therapy.

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Available as dietary supplement

Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).

503B pharmacies · 4

503B pharmacy

Empower Pharmacy

Rx required

One of the largest US compounders by volume; dual 503A + 503B. Repeat FDA enforcement history and ongoing Lilly litigation.

FDA 503B Registered6 flags on record
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503B pharmacy

Olympia Pharmaceuticals

Rx required

35+ year family-owned dual 503A/503B licensed in 48–49 states. Among the cleanest mid-sized 503Bs operating today.

FDA 503B Registered3 flags on record
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503B pharmacy

Belmar Pharma Solutions

Rx required

Webster Equity portfolio. Triple-credentialed (PCAB + NABP + LegitScript), licensed in all 50 states. Among the most credentialed operators.

FDA 503B Registered +31 flag on record
503B pharmacy

Fagron Sterile Services

Rx required

Established 503B outsourcing facility in FDA's registered list.

FDA 503B Registered

Telehealth (Rx) · 4

Telehealth

Defy Medical

Rx required

Broadest peptide formulary in legitimate US telehealth. 13-year history, concierge cash-pay, no known lawsuits.

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Telehealth

Ivim Health

Rx required

~100 providers. Filed amicus brief supporting OFA's tirzepatide appeal. Joined Outsourcing Facilities Association.

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Telehealth

Blokes / Joi Women's Wellness

Rx required

Men's + women's optimization platform. TRT in 34 states. 4.6–4.8 Trustpilot.

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Telehealth

Superpower

Rx required

Longevity-biomarker subscription ($199/yr, 100+ biomarkers) with narrow prescription formulary.

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Research-use-only · 1

Research-use-only

Limitless Life Nootropics

'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.

BBB Accredited +1
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Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Flushing and chest pressure (IV)
  • 02Nausea
  • 03Injection site pain

Contraindications

None specified.

§ 10   Questions

NAD+ FAQ

What is NAD+?
Central redox and signaling coenzyme; exogenous NAD+ or its precursors are used to support energy, repair, and longevity pathways. NAD+ is required for sirtuin, PARP, and CD38 activity. Cellular NAD+ declines with age. Restoring NAD+ or precursors (NMN/NR) is hypothesized to enhance mitochondrial function and DNA repair.
What is NAD+ used for?
Reported uses include energy and cognition anecdotally, mitochondrial support, and exploratory longevity interventions. Evidence strength is rated Preclinical — see the evidence section for detail.
How is NAD+ dosed?
Commonly referenced dosing is 50 – 250 mg SubQ or 250–1000 mg IV, typically 2–5x weekly, administered SubQ. This is educational reference only; consult a licensed clinician before use.
What are the side effects of NAD+?
Commonly reported side effects include flushing and chest pressure (iv), nausea, and injection site pain. This list is not exhaustive.
Is NAD+ legal?
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Not approved as a drug; marketed as supplement and IV therapy..
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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.