§ 01 Overview
Overview
Potent synthetic ghrelin receptor agonist hexapeptide approved in Japan (2006) as a GH-deficiency diagnostic.
Approved in Japan for GHD diagnosis. Extensive PK studies.
§ 02 Mechanism
Mechanism of action
GHRP-2 is a GHS-R1a agonist that triggers a robust GH pulse from the pituitary. It also raises appetite via central ghrelin signaling and has modest prolactin/cortisol effects.
- 01Strong GH pulse
- 02Approved in Japan as diagnostic for GH deficiency
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 300 mcg per dose
- Route
- SubQ
- Frequency
- 1–3x daily
- Cycle
- 8–12 weeks
§ 04 Evidence
Evidence & research
Approved in Japan for GHD diagnosis. Extensive PK studies.
FDA Status
Not FDA-approved. On FDA 503A Category 2 bulks list (2023).
§ 06 News
In the news
3 articles from the last 12 months · updates hourly
Nigerian-born Heavyweight Boxer Lawrence Okolie Blames Elbow Injury For Failed Drugs Test - Sports247 Nigeria
Nigerian-born Heavyweight Boxer Lawrence Okolie Blames Elbow Injury For Failed Drugs Test Sports247 Nigeria
British heavyweight sought to replace Lawrence Okolie against Tony Yoka - BoxingScene
British heavyweight sought to replace Lawrence Okolie against Tony Yoka BoxingScene
Synergistic Horizons: Exploring CJC-1295, Ipamorelin, and GHRP-2 Peptide Blend - Media Hindustan
Synergistic Horizons: Exploring CJC-1295, Ipamorelin, and GHRP-2 Peptide Blend Media Hindustan
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Research-use-only · 1
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§ 09 Safety
Safety & side effects
Side effects
- 01Hunger / appetite increase
- 02Mild cortisol and prolactin elevation
- 03Flushing
Contraindications
None specified.
§ 10 Questions
GHRP-2 FAQ
- What is GHRP-2?
- Potent synthetic ghrelin receptor agonist hexapeptide approved in Japan (2006) as a GH-deficiency diagnostic. GHRP-2 is a GHS-R1a agonist that triggers a robust GH pulse from the pituitary. It also raises appetite via central ghrelin signaling and has modest prolactin/cortisol effects.
- What is GHRP-2 used for?
- Reported uses include strong gh pulse and approved in japan as diagnostic for gh deficiency. Evidence strength is rated Clinical — see the evidence section for detail.
- How is GHRP-2 dosed?
- Commonly referenced dosing is 100 – 300 mcg per dose, typically 1–3x daily, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute GHRP-2?
- For GHRP-2, vials commonly come in 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of GHRP-2?
- Commonly reported side effects include hunger / appetite increase, mild cortisol and prolactin elevation, and flushing. This list is not exhaustive.
- Is GHRP-2 legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. On FDA 503A Category 2 bulks list (2023)..
§ 11 References
Selected references
- 01
Bowers Endocrinology
PMID: 6201310
- 02
Laferrère — meal and GHRP-2
PMID: 15705920