§ 01 Overview
Overview
First-generation ghrelin-receptor hexapeptide that strongly stimulates GH and appetite, with modest cortisol/prolactin effects.
Classic GHS. No FDA approval.
§ 02 Mechanism
Mechanism of action
GHRP-6 is a synthetic hexapeptide agonist of the ghrelin receptor (GHS-R1a). It produces robust GH release and notable hunger signaling via the same receptor.
- 01GH pulse
- 02Appetite stimulation (used for underweight patients anecdotally)
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 300 mcg per dose
- Route
- SubQ
- Frequency
- 1–3x daily
- Cycle
- 8–12 weeks
§ 04 Evidence
Evidence & research
Classic GHS. No FDA approval.
FDA Status
Not FDA-approved. On FDA 503A Category 2 bulks list.
§ 06 News
In the news
1 article from the last 12 months · updates hourly
Best Peptides for Athletic Performance in 2026: Top Picks for Muscle Growth, Recovery & Endurance - Iredell Free News
Best Peptides for Athletic Performance in 2026: Top Picks for Muscle Growth, Recovery & Endurance Iredell Free News
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Research-use-only · 1
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§ 09 Safety
Safety & side effects
Side effects
- 01Strong hunger
- 02Cortisol and prolactin elevation
- 03Flushing
Contraindications
None specified.
§ 10 Questions
GHRP-6 FAQ
- What is GHRP-6?
- First-generation ghrelin-receptor hexapeptide that strongly stimulates GH and appetite, with modest cortisol/prolactin effects. GHRP-6 is a synthetic hexapeptide agonist of the ghrelin receptor (GHS-R1a). It produces robust GH release and notable hunger signaling via the same receptor.
- What is GHRP-6 used for?
- Reported uses include gh pulse and appetite stimulation (used for underweight patients anecdotally). Evidence strength is rated Preclinical — see the evidence section for detail.
- How is GHRP-6 dosed?
- Commonly referenced dosing is 100 – 300 mcg per dose, typically 1–3x daily, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute GHRP-6?
- For GHRP-6, vials commonly come in 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of GHRP-6?
- Commonly reported side effects include strong hunger, cortisol and prolactin elevation, and flushing. This list is not exhaustive.
- Is GHRP-6 legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. On FDA 503A Category 2 bulks list..
§ 11 References
Selected references
- 01
Bowers Endocrinology
PMID: 6201310
- 02
Smith Science — ghrelin receptor identification
PMID: 8688086