§ 01 Overview
Overview
Methylated GHRP-6 analog hexapeptide; a potent ghrelin-receptor agonist with additional proposed cardioprotection via CD36.
Studied in PK and cardiac models. No FDA approval.
§ 02 Mechanism
Mechanism of action
Hexarelin is a GHS-R1a agonist with a second binding site at CD36 in cardiac tissue, which is hypothesized to confer cardioprotective effects beyond GH release.
- 01Strong GH pulse
- 02Proposed cardioprotective effects via CD36
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 100 – 200 mcg per dose
- Route
- SubQ
- Frequency
- 1–2x daily
- Cycle
- 4–8 weeks (tolerance develops)
§ 04 Evidence
Evidence & research
Studied in PK and cardiac models. No FDA approval.
FDA Status
Not FDA-approved. On FDA 503A Category 2 bulks list.
§ 06 News
In the news
4 articles from the last 12 months · updates hourly
Hexarelin Beyond Growth Hormone: Expanding Theoretical Horizons in Peptide Research - G Plus News
Hexarelin Beyond Growth Hormone: Expanding Theoretical Horizons in Peptide Research G Plus News
Examorelin: A Synthetic Growth Hormone–Releasing Peptide in Endocrine Signaling and Molecular Research - Dhaka Tribune
Examorelin: A Synthetic Growth Hormone–Releasing Peptide in Endocrine Signaling and Molecular Research Dhaka Tribune
Hexarelin Peptide: A Full Scientific Overview - WorldHealth.net
Hexarelin Peptide: A Full Scientific Overview WorldHealth.net
Public advisory - Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks - PR Newswire Canada
Public advisory - Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks PR Newswire Canada
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Research-use-only · 1
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§ 09 Safety
Safety & side effects
Side effects
- 01Cortisol and prolactin elevation
- 02Rapid receptor desensitization
Contraindications
None specified.
§ 10 Questions
Hexarelin FAQ
- What is Hexarelin?
- Methylated GHRP-6 analog hexapeptide; a potent ghrelin-receptor agonist with additional proposed cardioprotection via CD36. Hexarelin is a GHS-R1a agonist with a second binding site at CD36 in cardiac tissue, which is hypothesized to confer cardioprotective effects beyond GH release.
- What is Hexarelin used for?
- Reported uses include strong gh pulse and proposed cardioprotective effects via cd36. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Hexarelin dosed?
- Commonly referenced dosing is 100 – 200 mcg per dose, typically 1–2x daily, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute Hexarelin?
- For Hexarelin, vials commonly come in 5 mg and a common reconstitution is 2 ml BAC water. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of Hexarelin?
- Commonly reported side effects include cortisol and prolactin elevation and rapid receptor desensitization. This list is not exhaustive.
- Is Hexarelin legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved. On FDA 503A Category 2 bulks list..
§ 11 References
Selected references
- 01
Imbimbo JCEM
PMID: 8126144
- 02
Broglio — CD36 cardiac binding
PMID: 11932327