What is Palmitoyl Tripeptide-1 / Tetrapeptide-7?

A pair of lipidated signal peptides used in premium anti-aging skincare. Pal-Tripeptide-1 (Pal-GHK) stimulates collagen synthesis via the matrikine pathway; Pal-Tetrapeptide-7 (Pal-GQPR) reduces inflammation by inhibiting IL-6 release. Sold together as 'Haloxyl' for under-eye applications. Pal-Tripeptide-1 mimics a collagen degradation fragment (GHK) to signal fibroblasts to produce new collagen and fibronectin. Pal-Tetrapeptide-7 inhibits complement factor C5a-mediated IL-6 secretion, reducing chronic low-grade inflammation. The palmitoyl (C16) moiety enhances skin penetration.

What is Palmitoyl Tripeptide-1 / Tetrapeptide-7 used for?

Reported uses include stimulates collagen i, iii, and iv, reduces inflammatory cytokines in aged skin, clinically demonstrated reduction in under-eye dark circles (haloxyl blend), and widely used in luxury skincare formulations. Evidence strength is rated Clinical — see the evidence section for detail.

How is Palmitoyl Tripeptide-1 / Tetrapeptide-7 dosed?

Commonly referenced dosing is 2–8% inclusion rate in serum formulations, typically daily, administered Topical. This is educational reference only; consult a licensed clinician before use.

What are the side effects of Palmitoyl Tripeptide-1 / Tetrapeptide-7?

Commonly reported side effects include rare skin irritation and generally very well tolerated topically. This list is not exhaustive.

Palmitoyl Tripeptide-1 / Tetrapeptide-7

§ 01 Overview

Overview

A pair of lipidated signal peptides used in premium anti-aging skincare. Pal-Tripeptide-1 (Pal-GHK) stimulates collagen synthesis via the matrikine pathway; Pal-Tetrapeptide-7 (Pal-GQPR) reduces inflammation by inhibiting IL-6 release. Sold together as 'Haloxyl' for under-eye applications.

Manufacturer-sponsored clinical trials show wrinkle reduction and under-eye improvement. Published efficacy data in Journal of Cosmetic Dermatology. Cosmetic ingredient, not FDA-regulated as a drug. Less independent data than GHK-Cu.

§ 02 Mechanism

Mechanism of action

Pal-Tripeptide-1 mimics a collagen degradation fragment (GHK) to signal fibroblasts to produce new collagen and fibronectin. Pal-Tetrapeptide-7 inhibits complement factor C5a-mediated IL-6 secretion, reducing chronic low-grade inflammation. The palmitoyl (C16) moiety enhances skin penetration.

01Stimulates collagen I, III, and IV
02Reduces inflammatory cytokines in aged skin
03Clinically demonstrated reduction in under-eye dark circles (Haloxyl blend)
04Widely used in luxury skincare formulations

§ 03 Dosing

Dosing protocol

Standard Protocol

Dose Range: 2–8% inclusion rate in serum formulations
Starting Dose: Apply topically 1–2× daily
Route: Topical
Timing: AM and/or PM
Frequency: Daily
Cycle: Continuous use

Storage

Room temperature; protect from light.

§ 04 Evidence

Evidence & research

Clinical

FDA Status

Cosmetic ingredient; no FDA drug approval required.

§ 05 Stacks

Common stacks

GHK-Cu

Complementary copper-peptide signaling

Matrixyl (Palmitoyl Pentapeptide-4)

Collagen-stimulating peptide layering

Snap-8

Topical anti-aging stack

§ 06 News

In the news

1 article from the last 12 months · updates hourly

Liverpool EchoMar 19, 2026

Best-selling 'dark circle eraser' with 66,000 reviews reduced to £6 - Liverpool Echo

Best-selling 'dark circle eraser' with 66,000 reviews reduced to £6 Liverpool Echo

§ 07 Sourcing

Sourcing & supply

Regulatory status

Available as dietary supplement

Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

Browse full supplier directory

§ 09 Safety

Safety & side effects

Side effects

01Rare skin irritation
02Generally very well tolerated topically

Contraindications

01Known sensitivity to peptide cosmetic ingredients

§ 10 Questions

Palmitoyl Tripeptide-1 / Tetrapeptide-7 FAQ

What is Palmitoyl Tripeptide-1 / Tetrapeptide-7?: A pair of lipidated signal peptides used in premium anti-aging skincare. Pal-Tripeptide-1 (Pal-GHK) stimulates collagen synthesis via the matrikine pathway; Pal-Tetrapeptide-7 (Pal-GQPR) reduces inflammation by inhibiting IL-6 release. Sold together as 'Haloxyl' for under-eye applications. Pal-Tripeptide-1 mimics a collagen degradation fragment (GHK) to signal fibroblasts to produce new collagen and fibronectin. Pal-Tetrapeptide-7 inhibits complement factor C5a-mediated IL-6 secretion, reducing chronic low-grade inflammation. The palmitoyl (C16) moiety enhances skin penetration.
What is Palmitoyl Tripeptide-1 / Tetrapeptide-7 used for?: Reported uses include stimulates collagen i, iii, and iv, reduces inflammatory cytokines in aged skin, clinically demonstrated reduction in under-eye dark circles (haloxyl blend), and widely used in luxury skincare formulations. Evidence strength is rated Clinical — see the evidence section for detail.
How is Palmitoyl Tripeptide-1 / Tetrapeptide-7 dosed?: Commonly referenced dosing is 2–8% inclusion rate in serum formulations, typically daily, administered Topical. This is educational reference only; consult a licensed clinician before use.
What are the side effects of Palmitoyl Tripeptide-1 / Tetrapeptide-7?: Commonly reported side effects include rare skin irritation and generally very well tolerated topically. This list is not exhaustive.
Is Palmitoyl Tripeptide-1 / Tetrapeptide-7 legal?: Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Cosmetic ingredient; no FDA drug approval required..

§ 11 References

Selected references

01
Lintner — Int J Cosmet Sci 2009
PMID: 19134127
02
Farwick — J Cosmet Laser Ther 2011
PMID: 21635202