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Peptide.Guide
PreclinicalMitochondrialSubQResearchPartial data

SHLP-2

Small Humanin-Like Peptide 2

Mitochondrial-derived peptide (~26 aa from 16S rRNA) that enhances mitochondrial metabolism and insulin sensitivity.

Read dosing protocolJump to references

§ 01   Overview

Overview

Mitochondrial-derived peptide (~26 aa from 16S rRNA) that enhances mitochondrial metabolism and insulin sensitivity.

Characterized by Cobb et al. 2016; mechanism and biomarker studies since.

§ 02   Mechanism

Mechanism of action

SHLP-2 is a short ORF product of the mitochondrial 16S rRNA. It enhances mitochondrial respiration and insulin sensitivity, and circulating levels correlate inversely with prostate-cancer and T2D risk.

  • 01Improved mitochondrial metabolism (preclinical)
  • 02Insulin-sensitizing effects
  • 03Candidate biomarker for metabolic aging

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
Not characterized in humans
Route
SubQ
Frequency
Research

§ 04   Evidence

Evidence & research

Preclinical

Characterized by Cobb et al. 2016; mechanism and biomarker studies since.

FDA Status

Not FDA-approved.

§ 07   Sourcing

Sourcing & supply

Regulatory status

Research-only, no commercial channel

No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

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§ 09   Safety

Safety & side effects

Side effects

  • 01Unknown in humans

Contraindications

None specified.

§ 10   Questions

SHLP-2 FAQ

What is SHLP-2?
Mitochondrial-derived peptide (~26 aa from 16S rRNA) that enhances mitochondrial metabolism and insulin sensitivity. SHLP-2 is a short ORF product of the mitochondrial 16S rRNA. It enhances mitochondrial respiration and insulin sensitivity, and circulating levels correlate inversely with prostate-cancer and T2D risk.
What is SHLP-2 used for?
Reported uses include improved mitochondrial metabolism (preclinical), insulin-sensitizing effects, and candidate biomarker for metabolic aging. Evidence strength is rated Preclinical — see the evidence section for detail.
How is SHLP-2 dosed?
Commonly referenced dosing is Not characterized in humans, typically research, administered SubQ. This is educational reference only; consult a licensed clinician before use.
What are the side effects of SHLP-2?
Commonly reported side effects include unknown in humans. This list is not exhaustive.
Is SHLP-2 legal?
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved..

§ 11   References

Selected references

  1. 01

    Cobb Aging 2016

    PMID: 27008381

  2. 02

    Okada JBC 2017

    PMID: 28928220

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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.