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Peptide.Guide
PreclinicalMitochondrialSubQResearchPartial data

SHLP-6

Small Humanin-Like Peptide 6

Mitochondrial-derived peptide that, in contrast to SHLP-2, is pro-apoptotic in cancer cell lines: a candidate tumor-suppressive MDP.

Read dosing protocolJump to references

§ 01   Overview

Overview

Mitochondrial-derived peptide that, in contrast to SHLP-2, is pro-apoptotic in cancer cell lines: a candidate tumor-suppressive MDP.

Cobb et al. 2016 and Kim Cell Metab review.

§ 02   Mechanism

Mechanism of action

SHLP-6 is another short ORF encoded within mitochondrial 16S rRNA. Unlike most MDPs, it promotes apoptosis in cancer cell lines, making it an interesting tumor-suppressive signal.

  • 01Pro-apoptotic in cancer models (preclinical)

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
Not characterized in humans
Route
SubQ
Frequency
Research

§ 04   Evidence

Evidence & research

Preclinical

Cobb et al. 2016 and Kim Cell Metab review.

FDA Status

Not FDA-approved.

§ 07   Sourcing

Sourcing & supply

Regulatory status

Research-only, no commercial channel

No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

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§ 09   Safety

Safety & side effects

Side effects

  • 01Unknown in humans

Contraindications

None specified.

§ 10   Questions

SHLP-6 FAQ

What is SHLP-6?
Mitochondrial-derived peptide that, in contrast to SHLP-2, is pro-apoptotic in cancer cell lines: a candidate tumor-suppressive MDP. SHLP-6 is another short ORF encoded within mitochondrial 16S rRNA. Unlike most MDPs, it promotes apoptosis in cancer cell lines, making it an interesting tumor-suppressive signal.
What is SHLP-6 used for?
Reported uses include pro-apoptotic in cancer models (preclinical). Evidence strength is rated Preclinical — see the evidence section for detail.
How is SHLP-6 dosed?
Commonly referenced dosing is Not characterized in humans, typically research, administered SubQ. This is educational reference only; consult a licensed clinician before use.
What are the side effects of SHLP-6?
Commonly reported side effects include unknown in humans. This list is not exhaustive.
Is SHLP-6 legal?
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved..

§ 11   References

Selected references

  1. 01

    Cobb Aging 2016

    PMID: 27008381

  2. 02

    Kim Cell Metab review

    PMID: 28380375

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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.