Zinc-dependent nonapeptide (FTS) secreted by thymic epithelial cells. Activity absolutely requires a bound zinc ion; 'Zn-thymulin' is the active form. Studied for immune restoration, allergic disease, and neuroinflammation. Thymulin binds a zinc ion in a 1:1 stoichiometry; the Zn-bound form promotes T-cell differentiation and restores CD4/CD8 balance in immunosenescent or zinc-deficient states. Anti-inflammatory effects via suppression of NF-κB-driven cytokines.

What is Thymulin used for?

Reported uses include restores t-cell function in age- or zinc-related immunodeficiency, anti-inflammatory signaling in cns models, and historical research depth from french/italian immunology groups. Evidence strength is rated Preclinical — see the evidence section for detail.

How is Thymulin dosed?

Commonly referenced dosing is 5 – 10 mg per course (research), typically daily for 10–20 days, administered SubQ. This is educational reference only; consult a licensed clinician before use.

What are the side effects of Thymulin?

Commonly reported side effects include limited published human data. This list is not exhaustive.

Thymulin | Peptide Guide

§ 01 Overview

Overview

Zinc-dependent nonapeptide (FTS) secreted by thymic epithelial cells. Activity absolutely requires a bound zinc ion; 'Zn-thymulin' is the active form. Studied for immune restoration, allergic disease, and neuroinflammation.

Well-characterized biology (Bach/Dardenne, 1970s–90s). Limited controlled human trials.

§ 02 Mechanism

Mechanism of action

Thymulin binds a zinc ion in a 1:1 stoichiometry; the Zn-bound form promotes T-cell differentiation and restores CD4/CD8 balance in immunosenescent or zinc-deficient states. Anti-inflammatory effects via suppression of NF-κB-driven cytokines.

01Restores T-cell function in age- or zinc-related immunodeficiency
02Anti-inflammatory signaling in CNS models
03Historical research depth from French/Italian immunology groups

§ 03 Dosing

Dosing protocol

Standard Protocol

Dose Range: 5 – 10 mg per course (research)
Route: SubQ
Frequency: Daily for 10–20 days
Cycle: 1–2 courses per year

§ 04 Evidence

Evidence & research

Preclinical

Well-characterized biology (Bach/Dardenne, 1970s–90s). Limited controlled human trials.

FDA Status

Not FDA-approved.

§ 07 Sourcing

Sourcing & supply

Regulatory status

Authentic supply from international sources

Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product.

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

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§ 09 Safety

Safety & side effects

Side effects

01Limited published human data

Contraindications

None specified.

§ 10 Questions

Thymulin FAQ

What is Thymulin?: Zinc-dependent nonapeptide (FTS) secreted by thymic epithelial cells. Activity absolutely requires a bound zinc ion; 'Zn-thymulin' is the active form. Studied for immune restoration, allergic disease, and neuroinflammation. Thymulin binds a zinc ion in a 1:1 stoichiometry; the Zn-bound form promotes T-cell differentiation and restores CD4/CD8 balance in immunosenescent or zinc-deficient states. Anti-inflammatory effects via suppression of NF-κB-driven cytokines.
What is Thymulin used for?: Reported uses include restores t-cell function in age- or zinc-related immunodeficiency, anti-inflammatory signaling in cns models, and historical research depth from french/italian immunology groups. Evidence strength is rated Preclinical — see the evidence section for detail.
How is Thymulin dosed?: Commonly referenced dosing is 5 – 10 mg per course (research), typically daily for 10–20 days, administered SubQ. This is educational reference only; consult a licensed clinician before use.
What are the side effects of Thymulin?: Commonly reported side effects include limited published human data. This list is not exhaustive.
Is Thymulin legal?: Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product. FDA status: Not FDA-approved..

§ 11 References

Selected references

01
Dardenne — Zn-thymulin biology
Bach Research in Endocrinology 1989