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Urolithin A (Mitopure)

Mitopure · UA

Urolithin A is generated by gut bacteria metabolizing ellagitannins (pomegranate, berries). Direct supplementation induces mitophagy and improves muscle endurance in RCTs.

Read dosing protocolJump to references

◆ Editorial note

Gut-microbiome-derived dibenzo-pyranone. Not a peptide.

§ 01   Overview

Overview

Urolithin A is generated by gut bacteria metabolizing ellagitannins (pomegranate, berries). Direct supplementation induces mitophagy and improves muscle endurance in RCTs.

Andreux 2019 Phase 1 and Singh 2022 RCT showed measurable functional improvements.

§ 02   Mechanism

Mechanism of action

Urolithin A induces mitophagy (the selective removal of damaged mitochondria), restoring mitochondrial quality in aged cells. Only ~40% of adults produce sufficient UA naturally, which is why direct supplementation matters.

  • 01Improved mitochondrial function in aged muscle
  • 02Increased muscle endurance / strength in RCTs
  • 03GRAS status for Mitopure

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
500 – 1000 mg daily
Route
Oral
Frequency
Daily
Cycle
4+ months to observe muscle effects

§ 04   Evidence

Evidence & research

Clinical

Andreux 2019 Phase 1 and Singh 2022 RCT showed measurable functional improvements.

FDA Status

Not a drug; GRAS as Mitopure dietary supplement.

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Available as dietary supplement

Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).

No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.

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§ 09   Safety

Safety & side effects

Side effects

  • 01Generally well tolerated

Contraindications

None specified.

§ 10   Questions

Urolithin A (Mitopure) FAQ

What is Urolithin A (Mitopure)?
Urolithin A is generated by gut bacteria metabolizing ellagitannins (pomegranate, berries). Direct supplementation induces mitophagy and improves muscle endurance in RCTs. Urolithin A induces mitophagy (the selective removal of damaged mitochondria), restoring mitochondrial quality in aged cells. Only ~40% of adults produce sufficient UA naturally, which is why direct supplementation matters.
What is Urolithin A (Mitopure) used for?
Reported uses include improved mitochondrial function in aged muscle, increased muscle endurance / strength in rcts, and gras status for mitopure. Evidence strength is rated Clinical — see the evidence section for detail.
How is Urolithin A (Mitopure) dosed?
Commonly referenced dosing is 500 – 1000 mg daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
What are the side effects of Urolithin A (Mitopure)?
Commonly reported side effects include generally well tolerated. This list is not exhaustive.
Is Urolithin A (Mitopure) legal?
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Not a drug; GRAS as Mitopure dietary supplement..

§ 11   References

Selected references

  1. 01

    Andreux Nat Metab 2019

    PMID: 32694802

  2. 02

    Singh Cell Rep Med 2022

    PMID: 35584623

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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.