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Enclomiphene

Androxal · trans-clomiphene

Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding.

Read dosing protocolJump to references

◆ Editorial note

Non-peptide SERM (trans-clomiphene isomer).

§ 01   Overview

Overview

Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding.

Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.

§ 02   Mechanism

Mechanism of action

Enclomiphene blocks hypothalamic ER to remove estrogen negative feedback, raising LH/FSH and driving endogenous testosterone. Unlike TRT, it preserves spermatogenesis, making it useful for men who want fertility and testosterone.

  • 01Raises endogenous testosterone
  • 02Preserves fertility vs. exogenous TRT
  • 03Oral daily dosing

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
12.5 – 25 mg daily
Route
Oral
Timing
AM
Frequency
Daily
Cycle
8–24 weeks

§ 04   Evidence

Evidence & research

Clinical

Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.

FDA Status

Not FDA-approved. Available via compounding.

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Compoundable via 503A/503B

This compound has a 503A/503B compounding pathway. State-licensed compounding pharmacies can prepare it with a valid prescription.

Telehealth (Rx) · 4

Telehealth

Hims & Hers

Rx required

All 50 states. Owns its own FDA-registered compounding facility. Under FDA scrutiny.

LegitScript Certified2 flags on record
Visit
Telehealth

Marek Health

Rx required

Premium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.

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Telehealth

Maximus Tribe

Rx required

Performance medicine platform. Flagship 'Oral TRT+' (enclomiphene + pregnenolone). Claims LegitScript-certified pharmacy partners.

1 flag on record
Visit
Telehealth

Fountain TRT / Fountain Vitality

Rx required

Urologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.

Visit

Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Hot flashes
  • 02Mood changes
  • 03Visual disturbances (rare)

Contraindications

None specified.

§ 10   Questions

Enclomiphene FAQ

What is Enclomiphene?
Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding. Enclomiphene blocks hypothalamic ER to remove estrogen negative feedback, raising LH/FSH and driving endogenous testosterone. Unlike TRT, it preserves spermatogenesis, making it useful for men who want fertility and testosterone.
What is Enclomiphene used for?
Reported uses include raises endogenous testosterone, preserves fertility vs. exogenous trt, and oral daily dosing. Evidence strength is rated Clinical — see the evidence section for detail.
How is Enclomiphene dosed?
Commonly referenced dosing is 12.5 – 25 mg daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
What are the side effects of Enclomiphene?
Commonly reported side effects include hot flashes, mood changes, and visual disturbances (rare). This list is not exhaustive.
Is Enclomiphene legal?
This compound has a 503A/503B compounding pathway. State-licensed compounding pharmacies can prepare it with a valid prescription. FDA status: Not FDA-approved. Available via compounding..

§ 11   References

Selected references

  1. 01

    Kim BJU Int 2016

    PMID: 26691698

  2. 02

    Wiehle BJU Int 2014

    PMID: 24127807

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This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.