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Enclomiphene

Androxal · trans-clomiphene

Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding.

Read dosing protocolJump to references

◆ Editorial note

Non-peptide SERM (trans-clomiphene isomer).

§ 01   Overview

Overview

Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding.

Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.

§ 02   Mechanism

Mechanism of action

Enclomiphene blocks hypothalamic ER to remove estrogen negative feedback, raising LH/FSH and driving endogenous testosterone. Unlike TRT, it preserves spermatogenesis, making it useful for men who want fertility and testosterone.

  • 01Raises endogenous testosterone
  • 02Preserves fertility vs. exogenous TRT
  • 03Oral daily dosing

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
12.5 – 25 mg daily
Route
Oral
Timing
AM
Frequency
Daily
Cycle
8–24 weeks

§ 04   Evidence

Evidence & research

Clinical

Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.

FDA Status

Not FDA-approved. Available via compounding.

§ 06   News

In the news

8 articles from the last 12 months · updates hourly

§ 07   Sourcing

Sourcing & supply

Regulatory status

Compoundable via 503A/503B

This compound has a 503A/503B compounding pathway. State-licensed compounding pharmacies can prepare it with a valid prescription.

Telehealth (Rx) · 4

Telehealth

Hims & Hers

Rx required

All 50 states. Owns its own FDA-registered compounding facility. Under FDA scrutiny.

LegitScript Certified2 flags on record
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Telehealth

Marek Health

Rx required

Premium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.

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Telehealth

Maximus Tribe

Rx required

Performance medicine platform. Flagship 'Oral TRT+' (enclomiphene + pregnenolone). Claims LegitScript-certified pharmacy partners.

1 flag on record
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Telehealth

Fountain TRT / Fountain Vitality

Rx required

Urologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.

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Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Hot flashes
  • 02Mood changes
  • 03Visual disturbances (rare)

Contraindications

None specified.

§ 10   References

Selected references

  1. 01

    Kim BJU Int 2016

    PMID: 26691698

  2. 02

    Wiehle BJU Int 2014

    PMID: 24127807

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