§ 01 Overview
Overview
Hypothalamic estrogen-receptor antagonist that raises endogenous LH/FSH and testosterone while preserving spermatogenesis. FDA rejected the Androxal NDA in 2015; available via compounding.
Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.
§ 02 Mechanism
Mechanism of action
Enclomiphene blocks hypothalamic ER to remove estrogen negative feedback, raising LH/FSH and driving endogenous testosterone. Unlike TRT, it preserves spermatogenesis, making it useful for men who want fertility and testosterone.
- 01Raises endogenous testosterone
- 02Preserves fertility vs. exogenous TRT
- 03Oral daily dosing
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 12.5 – 25 mg daily
- Route
- Oral
- Timing
- AM
- Frequency
- Daily
- Cycle
- 8–24 weeks
§ 04 Evidence
Evidence & research
Multiple Phase 3 trials; FDA rejected the NDA in 2015 despite efficacy signal.
FDA Status
Not FDA-approved. Available via compounding.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Changes in Serum Testosterone After Sublingual Enclomiphene Citrate Combined With a Mineral Oxide Delivery System: A Retrospective Case Series of 15 Men - Cureus
Changes in Serum Testosterone After Sublingual Enclomiphene Citrate Combined With a Mineral Oxide Delivery System: A Retrospective Case Series of 15 Men Cureus
Enclomiphene Erectile Dysfunction: Exploring Its Role in Men's Hormonal Health - Portal CNJ
Enclomiphene Erectile Dysfunction: Exploring Its Role in Men's Hormonal Health Portal CNJ
Enclomiphene and Erectile Dysfunction: What Men Need to Know About This Testosterone Option - Portal CNJ
Enclomiphene and Erectile Dysfunction: What Men Need to Know About This Testosterone Option Portal CNJ
Does Enclomiphene Cause Erectile Dysfunction? - Portal CNJ
Does Enclomiphene Cause Erectile Dysfunction? Portal CNJ
Enclomiphene and erectile dysfunction: what men need to know - Portal CNJ
Enclomiphene and erectile dysfunction: what men need to know Portal CNJ
Enclomiphene penis growth: what the evidence actually shows - Portal CNJ
Enclomiphene penis growth: what the evidence actually shows Portal CNJ
HIMS stock's rally may have plenty of room left: FDA opens door to testosterone therapy - MSN
HIMS stock's rally may have plenty of room left: FDA opens door to testosterone therapy MSN
Dad speaks out after teen ordered banned testosterone booster online - CBC
Dad speaks out after teen ordered banned testosterone booster online CBC
§ 07 Sourcing
Sourcing & supply
Regulatory status
Compoundable via 503A/503B
This compound has a 503A/503B compounding pathway. State-licensed compounding pharmacies can prepare it with a valid prescription.
Telehealth (Rx) · 4
Hims & Hers
Rx requiredAll 50 states. Owns its own FDA-registered compounding facility. Under FDA scrutiny.
Marek Health
Rx requiredPremium hormone optimization. All 50 states. 4.8 Trustpilot. Partners include Hallandale.
Maximus Tribe
Rx requiredPerformance medicine platform. Flagship 'Oral TRT+' (enclomiphene + pregnenolone). Claims LegitScript-certified pharmacy partners.
Fountain TRT / Fountain Vitality
Rx requiredUrologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Hot flashes
- 02Mood changes
- 03Visual disturbances (rare)
Contraindications
None specified.
§ 10 References
Selected references
- 01
Kim BJU Int 2016
PMID: 26691698
- 02
Wiehle BJU Int 2014
PMID: 24127807