§ 01 Overview
Overview
Long-acting PDE5 inhibitor used for erectile dysfunction, BPH, and pulmonary hypertension.
FDA-approved for multiple indications with extensive clinical data.
§ 02 Mechanism
Mechanism of action
Tadalafil inhibits PDE5, preserving cGMP in smooth muscle and promoting vasodilation. Its ~17.5-hour half-life makes daily low-dose protocols possible.
- 01Treatment of erectile dysfunction
- 02Improves LUTS in BPH
- 03Possible cardiovascular effects (off-label)
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 2.5 – 20 mg
- Starting Dose
- 5 mg daily or 10 mg PRN
- Route
- Oral
- Timing
- Any time
- Frequency
- Daily or as needed
§ 04 Evidence
Evidence & research
FDA-approved for multiple indications with extensive clinical data.
FDA Status
FDA-approved (ED, BPH, pulmonary hypertension).
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Using tadalafil and tamsulosin together – a (haemo)dynamic duo? - NZ Doctor
Using tadalafil and tamsulosin together – a (haemo)dynamic duo? NZ Doctor
‘Sexual Chocolate’ Faces Recalls After FDA Tests Reveal Undisclosed Viagra - WIRED
‘Sexual Chocolate’ Faces Recalls After FDA Tests Reveal Undisclosed Viagra WIRED
Prime Male or Tadalafil: A Clinical Review for Men Over 40 - Ministerio de Salud Pública de Tucumán
Prime Male or Tadalafil: A Clinical Review for Men Over 40 Ministerio de Salud Pública de Tucumán
Big Dick Energy! may be harmful due to hidden drug ingredient - fda.gov
Big Dick Energy! may be harmful due to hidden drug ingredient fda.gov
Tadalafil Headache: Causes, Management Strategies, and Smarter Approaches - Portal CNJ
Tadalafil Headache: Causes, Management Strategies, and Smarter Approaches Portal CNJ
Tadalafil Daily Reddit: Real User Experiences, Benefits, and Practical Considerations - Portal CNJ
Tadalafil Daily Reddit: Real User Experiences, Benefits, and Practical Considerations Portal CNJ
Does 5mg of Cialis Work? A Practical Look at Daily Low-Dose Tadalafil - Portal CNJ
Does 5mg of Cialis Work? A Practical Look at Daily Low-Dose Tadalafil Portal CNJ
I cannot generate this article. - Portal CNJ
I cannot generate this article. Portal CNJ
§ 07 Sourcing
Sourcing & supply
Regulatory status
FDA-approved
This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status.
Telehealth (Rx) · 3
Maximus Tribe
Rx requiredPerformance medicine platform. Flagship 'Oral TRT+' (enclomiphene + pregnenolone). Claims LegitScript-certified pharmacy partners.
Fountain TRT / Fountain Vitality
Rx requiredUrologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.
Superpower
Rx requiredLongevity-biomarker subscription ($199/yr, 100+ biomarkers) with narrow prescription formulary.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Headache
- 02Back pain / myalgia
- 03Flushing
- 04Rare: priapism, vision changes
Contraindications
- 01Nitrate medications
- 02Severe cardiovascular disease