§ 01 Overview
Overview
Long-acting PDE5 inhibitor used for erectile dysfunction, BPH, and pulmonary hypertension.
FDA-approved for multiple indications with extensive clinical data.
§ 02 Mechanism
Mechanism of action
Tadalafil inhibits PDE5, preserving cGMP in smooth muscle and promoting vasodilation. Its ~17.5-hour half-life makes daily low-dose protocols possible.
- 01Treatment of erectile dysfunction
- 02Improves LUTS in BPH
- 03Possible cardiovascular effects (off-label)
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 2.5 – 20 mg
- Starting Dose
- 5 mg daily or 10 mg PRN
- Route
- Oral
- Timing
- Any time
- Frequency
- Daily or as needed
§ 04 Evidence
Evidence & research
FDA-approved for multiple indications with extensive clinical data.
FDA Status
FDA-approved (ED, BPH, pulmonary hypertension).
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
When a patient with erectile dysfunction is prescribed tadalafil - KMU
When a patient with erectile dysfunction is prescribed tadalafil KMU
Using tadalafil and tamsulosin together – a (haemo)dynamic duo? - PharmacyToday
Using tadalafil and tamsulosin together – a (haemo)dynamic duo? PharmacyToday
Grakcu capsules contain undeclared sildenafil and tadalafil. - Springer Nature Link
Grakcu capsules contain undeclared sildenafil and tadalafil. Springer Nature Link
Cialis and women: Discover effects and benefits - WSOC TV
Cialis and women: Discover effects and benefits WSOC TV
Keeps Powerhouse Review 2026: What Men Should Know About the 3-in-1 ED Telehealth Formula Before Starting Online Intake - Newswire.com
Keeps Powerhouse Review 2026: What Men Should Know About the 3-in-1 ED Telehealth Formula Before Starting Online Intake Newswire.com
Erectile Dysfunction Pills Tadalafil: A Practical Guide for Informed Users - Universidade do Porto
Erectile Dysfunction Pills Tadalafil: A Practical Guide for Informed Users Universidade do Porto
Opella Calls On Japan To ‘EnD The Joke’ As Cialis Switch Approved - insights.citeline.com
Opella Calls On Japan To ‘EnD The Joke’ As Cialis Switch Approved insights.citeline.com
Barcelona and L'Hospitalet remove 60 liters with sildenafil and tadalafil: 2 responsible individuals arrested - APD Noticies
Barcelona and L'Hospitalet remove 60 liters with sildenafil and tadalafil: 2 responsible individuals arrested APD Noticies
§ 07 Sourcing
Sourcing & supply
Regulatory status
FDA-approved
This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status.
Telehealth (Rx) · 3
Maximus Tribe
Rx requiredPerformance medicine platform. Flagship 'Oral TRT+' (enclomiphene + pregnenolone). Claims LegitScript-certified pharmacy partners.
Fountain TRT / Fountain Vitality
Rx requiredUrologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.
Superpower
Rx requiredLongevity-biomarker subscription ($199/yr, 100+ biomarkers) with narrow prescription formulary.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Headache
- 02Back pain / myalgia
- 03Flushing
- 04Rare: priapism, vision changes
Contraindications
- 01Nitrate medications
- 02Severe cardiovascular disease
§ 10 Questions
Tadalafil FAQ
- What is Tadalafil?
- Long-acting PDE5 inhibitor used for erectile dysfunction, BPH, and pulmonary hypertension. Tadalafil inhibits PDE5, preserving cGMP in smooth muscle and promoting vasodilation. Its ~17.5-hour half-life makes daily low-dose protocols possible.
- What is Tadalafil used for?
- Reported uses include treatment of erectile dysfunction, improves luts in bph, and possible cardiovascular effects (off-label). Evidence strength is rated Established — see the evidence section for detail.
- How is Tadalafil dosed?
- Commonly referenced dosing is 2.5 – 20 mg, typically daily or as needed, administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Tadalafil?
- Commonly reported side effects include headache, back pain / myalgia, flushing, and rare: priapism, vision changes. This list is not exhaustive.
- Is Tadalafil legal?
- This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status. FDA status: FDA-approved (ED, BPH, pulmonary hypertension)..