§ 01 Overview
Overview
Melanocortin receptor agonist that acts centrally to increase sexual desire and arousal in both sexes.
FDA-approved (Vyleesi, 2019) for HSDD in premenopausal women. Phase III RECONNECT trials.
§ 02 Mechanism
Mechanism of action
PT-141 is a cyclic heptapeptide that activates MC3R and MC4R in the CNS, driving dopaminergic pathways associated with sexual motivation, independent of the vascular mechanism of PDE5 inhibitors.
- 01FDA-approved for HSDD in premenopausal women
- 02Increased arousal in both sexes
- 03Works centrally, not vascular-dependent
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 10 mg
- BAC Water
- 2 ml BAC water
- Dose Range
- 1 – 2 mg as needed
- Starting Dose
- 1 mg SubQ 45–60 min before activity
- Route
- SubQ
- Timing
- 45–60 min pre-activity
- Frequency
- As needed, max 8 doses/month
§ 04 Evidence
Evidence & research
FDA-approved (Vyleesi, 2019) for HSDD in premenopausal women. Phase III RECONNECT trials.
FDA Status
FDA-approved (HSDD, women).
§ 06 News
In the news
6 articles from the last 12 months · updates hourly
Peptide Penis Growth: What the Evidence Actually Shows for Men Seeking Real Options - NTNU
Peptide Penis Growth: What the Evidence Actually Shows for Men Seeking Real Options NTNU
Penis Enlargement Peptides: What the Evidence Actually Shows - qsr.mlit.go.jp
Penis Enlargement Peptides: What the Evidence Actually Shows qsr.mlit.go.jp
Palatin Technologies Stock Faces Volatility Amid bremelanotide Patent Developments and Clinical Pipe - AD HOC NEWS
Palatin Technologies Stock Faces Volatility Amid bremelanotide Patent Developments and Clinical Pipe AD HOC NEWS
Palatin Technologies stock faces volatility amid bremelanotide sales updates and pipeline advancemen - AD HOC NEWS
Palatin Technologies stock faces volatility amid bremelanotide sales updates and pipeline advancemen AD HOC NEWS
The Peptide Boom Is Getting Out of Hand - The Atlantic
The Peptide Boom Is Getting Out of Hand The Atlantic
Top Peptides for 2025–2026: Mots-C, PT-141, KLOW Blend, GLOW Blend and More - A Listicle Guide - MSN
Top Peptides for 2025–2026: Mots-C, PT-141, KLOW Blend, GLOW Blend and More - A Listicle Guide MSN
§ 07 Sourcing
Sourcing & supply
Regulatory status
FDA-approved
This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status.
503B pharmacies · 4
Empower Pharmacy
Rx requiredOne of the largest US compounders by volume; dual 503A + 503B. Repeat FDA enforcement history and ongoing Lilly litigation.
Olympia Pharmaceuticals
Rx required35+ year family-owned dual 503A/503B licensed in 48–49 states. Among the cleanest mid-sized 503Bs operating today.
Fagron Sterile Services
Rx requiredEstablished 503B outsourcing facility in FDA's registered list.
Wedgewood Connect
Rx requiredFDA-registered 503B outsourcing facility.
Telehealth (Rx) · 2
International · 2
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Research-use-only · 3
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Nausea (most common)
- 02Flushing
- 03Transient blood pressure increase
- 04Skin darkening with repeated use
Contraindications
- 01Uncontrolled hypertension
- 02Cardiovascular disease