§ 01 Overview
Overview
Upstream driver of pulsatile GnRH release; investigational for HSDD, functional hypothalamic amenorrhea, and OHSS-free oocyte triggering in IVF.
Dhillon Dhillo Lab (Imperial) has run multiple Phase 2 studies.
§ 02 Mechanism
Mechanism of action
Kisspeptin (from the KISS1 gene) binds KISS1R/GPR54 on hypothalamic neurons to drive pulsatile GnRH release. It sits upstream of the entire HPG axis and is a candidate for conditions where pulsatile LH/FSH is needed without supraphysiological triggering.
- 01OHSS-free oocyte maturation in IVF
- 02Arousal effects (HSDD Phase 2)
- 03Restoration of cyclicity in hypothalamic amenorrhea
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- Trial-dependent (3.2 – 19.2 nmol/kg)
- Route
- SubQ
- Frequency
- Trial-dependent
§ 04 Evidence
Evidence & research
Dhillon Dhillo Lab (Imperial) has run multiple Phase 2 studies.
FDA Status
Investigational. Not FDA-approved.
§ 06 News
In the news
5 articles from the last 12 months · updates hourly
Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO–HPT–HPA Axes in Perimenopausal Reproductive Health - Wiley Online Library
Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO–HPT–HPA Axes in Perimenopausal Reproductive Health Wiley Online Library
Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice - Nature
Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice Nature
Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation - Endocrine Society
Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation Endocrine Society
Journal of Neuroendocrinology | BSN Journal - Wiley Online Library
Journal of Neuroendocrinology | BSN Journal Wiley Online Library
Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer - Nature
Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer Nature
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
Research-use-only · 1
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§ 09 Safety
Safety & side effects
Side effects
- 01Mild GI effects
- 02Limited long-term data
Contraindications
None specified.
§ 10 Questions
Kisspeptin FAQ
- What is Kisspeptin?
- Upstream driver of pulsatile GnRH release; investigational for HSDD, functional hypothalamic amenorrhea, and OHSS-free oocyte triggering in IVF. Kisspeptin (from the KISS1 gene) binds KISS1R/GPR54 on hypothalamic neurons to drive pulsatile GnRH release. It sits upstream of the entire HPG axis and is a candidate for conditions where pulsatile LH/FSH is needed without supraphysiological triggering.
- What is Kisspeptin used for?
- Reported uses include ohss-free oocyte maturation in ivf, arousal effects (hsdd phase 2), and restoration of cyclicity in hypothalamic amenorrhea. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Kisspeptin dosed?
- Commonly referenced dosing is Trial-dependent (3.2 – 19.2 nmol/kg), administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Kisspeptin?
- Commonly reported side effects include mild gi effects and limited long-term data. This list is not exhaustive.
- Is Kisspeptin legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Investigational. Not FDA-approved..
§ 11 References
Selected references
- 01
Jayasena JCEM 2009
PMID: 19820030
- 02
Abbara — IVF triggering
PMID: 26098212
- 03
HSDD trial
NCT02692456