§ 01 Overview
Overview
Pituitary-like gonadotropin that mimics LH, used in fertility, hypogonadism, and post-TRT recovery protocols.
FDA-approved for fertility and hypogonadotropic hypogonadism. Well-characterized.
§ 02 Mechanism
Mechanism of action
HCG binds the LH receptor on Leydig cells (in men) to stimulate endogenous testosterone and progesterone synthesis, and on granulosa cells (in women) to support ovulation.
- 01Stimulates endogenous testosterone in men on TRT
- 02Preserves testicular function and fertility on TRT
- 03Induces ovulation in fertility protocols
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 250 – 750 IU per dose (TRT adjunct)
- Starting Dose
- 250 IU
- Route
- SubQ
- Timing
- Any time
- Frequency
- 2–3x weekly
- Cycle
- Alongside TRT or for fertility cycles
§ 04 Evidence
Evidence & research
FDA-approved for fertility and hypogonadotropic hypogonadism. Well-characterized.
FDA Status
FDA-approved (fertility, hypogonadism).
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
Kiewit, HCG cap first year on construction work with $250,000 gift to charities - Indiana Gazette Online
Kiewit, HCG cap first year on construction work with $250,000 gift to charities Indiana Gazette Online
HCG Launches ‘Left Right Kiya Kya?’ Campaign To Promote Year-Round Breast Awareness - BW Healthcare
HCG Launches ‘Left Right Kiya Kya?’ Campaign To Promote Year-Round Breast Awareness BW Healthcare
HCG wins 10-way auction for Bianca Pozzi picture book series - The Bookseller
HCG wins 10-way auction for Bianca Pozzi picture book series The Bookseller
HCG, Apollo Hospitals, Max, Fortis Health share price could see further pressure today; Here's why - CNBC TV18
HCG, Apollo Hospitals, Max, Fortis Health share price could see further pressure today; Here's why CNBC TV18
HCG 5000 IU: Presentation, Dosing and Why the Number on the Vial Matters - Yonkers Times
HCG 5000 IU: Presentation, Dosing and Why the Number on the Vial Matters Yonkers Times
DEP TO HOLD MEETING, HEARING TONIGHT ON HCG MODIFICATION APPLICATION - WCCS AM1160 & 101.1FM
DEP TO HOLD MEETING, HEARING TONIGHT ON HCG MODIFICATION APPLICATION WCCS AM1160 & 101.1FM
Health Canada warns of possible false positives in pregnancy test recall - Global News
Health Canada warns of possible false positives in pregnancy test recall Global News
HCG conducts Pediatric Cancer Awareness Event - IndiaMedToday
HCG conducts Pediatric Cancer Awareness Event IndiaMedToday
§ 07 Sourcing
Sourcing & supply
Regulatory status
FDA-approved
This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status.
503B pharmacies · 2
Empower Pharmacy
Rx requiredOne of the largest US compounders by volume; dual 503A + 503B. Repeat FDA enforcement history and ongoing Lilly litigation.
Fagron Sterile Services
Rx requiredEstablished 503B outsourcing facility in FDA's registered list.
Telehealth (Rx) · 1
Fountain TRT / Fountain Vitality
Rx requiredUrologist-led TRT + GLP-1 platform. 4-star Trustpilot. Distinct from Fountain Life.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Elevated estrogen (men)
- 02Gynecomastia risk
- 03Injection site reactions
Contraindications
None specified.
§ 10 Questions
HCG FAQ
- What is HCG?
- Pituitary-like gonadotropin that mimics LH, used in fertility, hypogonadism, and post-TRT recovery protocols. HCG binds the LH receptor on Leydig cells (in men) to stimulate endogenous testosterone and progesterone synthesis, and on granulosa cells (in women) to support ovulation.
- What is HCG used for?
- Reported uses include stimulates endogenous testosterone in men on trt, preserves testicular function and fertility on trt, and induces ovulation in fertility protocols. Evidence strength is rated Established — see the evidence section for detail.
- How is HCG dosed?
- Commonly referenced dosing is 250 – 750 IU per dose (TRT adjunct), typically 2–3x weekly, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of HCG?
- Commonly reported side effects include elevated estrogen (men), gynecomastia risk, and injection site reactions. This list is not exhaustive.
- Is HCG legal?
- This compound has an FDA approval for at least one indication. Brand pharmacy channels exist. Compounding may or may not be available depending on shortage status. FDA status: FDA-approved (fertility, hypogonadism)..