§ 01 Overview
Overview
Choline-delivery compound that raises brain choline and acetylcholine levels, commonly used as a nootropic.
Small clinical trials in cognitive decline. Sold widely as a supplement.
§ 02 Mechanism
Mechanism of action
Alpha-GPC (L-alpha-glycerylphosphorylcholine) crosses the blood-brain barrier and serves as a substrate for acetylcholine synthesis. It also contributes to phosphatidylcholine in neuronal membranes.
- 01Improved focus and memory in some studies
- 02Used in cognitive and athletic protocols
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 300 – 900 mg daily
- Starting Dose
- 300 mg
- Route
- Oral
- Timing
- AM
- Frequency
- Daily
§ 04 Evidence
Evidence & research
Small clinical trials in cognitive decline. Sold widely as a supplement.
FDA Status
Dietary supplement in the US.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
5 Supplements Experts Say Can Help Reduce Brain Fog And Support Memory For Women Over 40: Creatine, More - SheFinds
5 Supplements Experts Say Can Help Reduce Brain Fog And Support Memory For Women Over 40: Creatine, More SheFinds
Max Brain Review 2026: Does It Really Work - Health Web Magazine
Max Brain Review 2026: Does It Really Work Health Web Magazine
Powdered Energy Drink Mixes - Trend Hunter
Powdered Energy Drink Mixes Trend Hunter
Ghost Energy Sticks featuring the same formula as the energy drink - Stack3d
Ghost Energy Sticks featuring the same formula as the energy drink Stack3d
The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously - Wiley Online Library
The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously Wiley Online Library
Health Canada issues product recall notice for Max Slim Alpha-GPC + Citicoline nootropic supplement - Inside Halton
Health Canada issues product recall notice for Max Slim Alpha-GPC + Citicoline nootropic supplement Inside Halton
Health Canada issues product recall notice for Max Slim Alpha-GPC + Citicoline nootropic supplement - Toronto Star
Health Canada issues product recall notice for Max Slim Alpha-GPC + Citicoline nootropic supplement Toronto Star
Alpha Brain vs Focus Factor: Which Is Better 2026? - Athletic Insight
Alpha Brain vs Focus Factor: Which Is Better 2026? Athletic Insight
§ 07 Sourcing
Sourcing & supply
Regulatory status
Available as dietary supplement
Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A).
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01GI upset
- 02Headache
- 03Some observational data suggests possible stroke risk in long-term high use
Contraindications
None specified.
§ 10 Questions
Alpha-GPC FAQ
- What is Alpha-GPC?
- Choline-delivery compound that raises brain choline and acetylcholine levels, commonly used as a nootropic. Alpha-GPC (L-alpha-glycerylphosphorylcholine) crosses the blood-brain barrier and serves as a substrate for acetylcholine synthesis. It also contributes to phosphatidylcholine in neuronal membranes.
- What is Alpha-GPC used for?
- Reported uses include improved focus and memory in some studies and used in cognitive and athletic protocols. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Alpha-GPC dosed?
- Commonly referenced dosing is 300 – 900 mg daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Alpha-GPC?
- Commonly reported side effects include gi upset, headache, and some observational data suggests possible stroke risk in long-term high use. This list is not exhaustive.
- Is Alpha-GPC legal?
- Sold as a dietary supplement. Quality varies widely by brand; prefer GRAS-designated products with third-party testing (e.g. Mitopure for Urolithin A). FDA status: Dietary supplement in the US..