§ 01 Overview
Overview
Synthetic ACTH(4-10) analog developed in Russia for stroke rehabilitation and cognitive enhancement.
Approved in Russia since the 1990s. Limited Western trial data. Strong preclinical and Russian clinical body.
§ 02 Mechanism
Mechanism of action
Semax upregulates BDNF and NGF expression, enhances dopaminergic and serotonergic signaling, and modulates enkephalin degradation. It crosses the blood-brain barrier and has well-documented nootropic effects in Russian clinical use.
- 01Improved focus and mental clarity
- 02Reduced mental fatigue under stress
- 03Neuroprotective effects after ischemia (preclinical)
- 04Adjunct in stroke rehabilitation (Russia)
§ 03 Dosing
Dosing protocol
Standard Protocol
- Vial
- 5 mg
- BAC Water
- 1 ml BAC water (intranasal) or per protocol
- Dose Range
- 250 – 1000 mcg per dose
- Starting Dose
- 300 mcg intranasal
- Route
- Intranasal
- Timing
- AM
- Frequency
- Daily or 2x per week
- Cycle
- 4–8 weeks
§ 04 Evidence
Evidence & research
Approved in Russia since the 1990s. Limited Western trial data. Strong preclinical and Russian clinical body.
FDA Status
Not FDA-approved.
§ 05 Stacks
Common stacks
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
American Peptides LOOT10 Promo Code: Up to 30% Off SEMAX, SELANK, ADAMAX, DIHEXA, PE-22-28 & P-21 - steady.page
American Peptides LOOT10 Promo Code: Up to 30% Off SEMAX, SELANK, ADAMAX, DIHEXA, PE-22-28 & P-21 steady.page
FDA advisers narrowly vote to add 6 peptides to a drug compounding list. What's next? - ABC News - Breaking News, Latest News and Videos
FDA advisers narrowly vote to add 6 peptides to a drug compounding list. What's next? ABC News - Breaking News, Latest News and Videos
Gym Rats Made Peptides Go Viral. California Trim Clinic Says Peptides Need More Than Mystery Vials! - PR Underground
Gym Rats Made Peptides Go Viral. California Trim Clinic Says Peptides Need More Than Mystery Vials! PR Underground
DIY peptide injections are risky, and people may make serious mistakes when administering them - The Conversation
DIY peptide injections are risky, and people may make serious mistakes when administering them The Conversation
Semax Polska Expands Scientific Education Platform with Hundreds of Literature-Based Resources Supporting Research Peptides and Modern Life Science Research - Barchart.com
Semax Polska Expands Scientific Education Platform with Hundreds of Literature-Based Resources Supporting Research Peptides and Modern Life Science Research Barchart.com
FDA Panel Backs 6 Peptides for Compounding - The American Journal of Managed Care
FDA Panel Backs 6 Peptides for Compounding The American Journal of Managed Care
FDA Panel Backs Peptide BPC-157 for Compounding in 8-6 Vote Over Scientists' Objections - Tech Times
FDA Panel Backs Peptide BPC-157 for Compounding in 8-6 Vote Over Scientists' Objections Tech Times
Peptide Safety and Cancer Risk: What You Need to Know - Dana-Farber Cancer Institute
Peptide Safety and Cancer Risk: What You Need to Know Dana-Farber Cancer Institute
§ 07 Sourcing
Sourcing & supply
Regulatory status
Restricted from compounding
Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales.
International · 3
Cosmic Nootropic
The most credible Russian / Khavinson source for US buyers. Sources authentic bioregulators through 'Peptides Company' (ex-NPCRIZ).
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Trident Peptides
1,299+ Trustpilot reviews (5-star). Strongest review base in UK research peptides. No visible ISO/GMP; COAs not posted.
Research-use-only · 5
Swiss Chems
Established SARMs/peptide vendor. FDA warning letter Dec 2024 for GLP-1s. Weaker peptide QC than SARMs QC.
Limitless Life Nootropics
'Only BBB-accredited peptide company' (since 2020). Claims three-lab third-party testing. Broad catalog.
Core Peptides
Broad catalog, widest payment range. Mid-credibility: Knoji 2.5/5 and one scam-impersonation report.
Modern Aminos
Multi-vial batch third-party testing. 5-star Trustpilot (1,400+ reviews). US- and EU-facing.
Peptide Warehouse
US-made, independent third-party testing including endotoxin and heavy-metal panels. Distinct from similar-sounding copycat domains.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Mild headache
- 02Irritation at intranasal application
Contraindications
None specified.
§ 10 Questions
Semax FAQ
- What is Semax?
- Synthetic ACTH(4-10) analog developed in Russia for stroke rehabilitation and cognitive enhancement. Semax upregulates BDNF and NGF expression, enhances dopaminergic and serotonergic signaling, and modulates enkephalin degradation. It crosses the blood-brain barrier and has well-documented nootropic effects in Russian clinical use.
- What is Semax used for?
- Reported uses include improved focus and mental clarity, reduced mental fatigue under stress, neuroprotective effects after ischemia (preclinical), and adjunct in stroke rehabilitation (russia). Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Semax dosed?
- Commonly referenced dosing is 250 – 1000 mcg per dose, typically daily or 2x per week, administered Intranasal. This is educational reference only; consult a licensed clinician before use.
- How do you reconstitute Semax?
- For Semax, vials commonly come in 5 mg and a common reconstitution is 1 ml BAC water (intranasal) or per protocol. Use the reconstitution calculator to convert any vial size and water volume into exact insulin-syringe units.
- What are the side effects of Semax?
- Commonly reported side effects include mild headache and irritation at intranasal application. This list is not exhaustive.
- Is Semax legal?
- Placed on the FDA's 503A Category 2 list and cannot be lawfully compounded in the US. No brand pharmacy alternative exists. US buyers encounter only research-use-only (RUO) channels, which the FDA's Intended Use Doctrine treats as unapproved drug sales. FDA status: Not FDA-approved..