§ 01 Overview
Overview
Angiotensin IV analog with potent synaptogenic activity in preclinical models; potency much higher than BDNF in some assays.
Rodent data only. No human trials.
§ 02 Mechanism
Mechanism of action
Dihexa binds and activates HGF/c-Met signaling, promoting dendritic spine formation and synaptogenesis in the hippocampus.
- 01Strong synaptogenesis in rodent models
- 02Proposed nootropic use
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 8 – 20 mg (research)
- Route
- Oral
- Frequency
- Daily
- Cycle
- Short cycles
§ 04 Evidence
Evidence & research
Rodent data only. No human trials.
FDA Status
Not FDA-approved.
§ 06 News
In the news
3 articles from the last 12 months · updates hourly
Umbrella Lab Announces Documentation And Traceability Update For Dihexa Peptide - GlobeNewswire
Umbrella Lab Announces Documentation And Traceability Update For Dihexa Peptide GlobeNewswire
FDA to Review 12 Peptides After Reversing High-Risk Classification - Greek City Times
FDA to Review 12 Peptides After Reversing High-Risk Classification Greek City Times
Integrative Health Miami Advances Personalized Nootropic Peptide Therapies for Cognitive Wellness - The Providence Journal
Integrative Health Miami Advances Personalized Nootropic Peptide Therapies for Cognitive Wellness The Providence Journal
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
- 01Active or prior cancer
§ 10 Questions
Dihexa FAQ
- What is Dihexa?
- Angiotensin IV analog with potent synaptogenic activity in preclinical models; potency much higher than BDNF in some assays. Dihexa binds and activates HGF/c-Met signaling, promoting dendritic spine formation and synaptogenesis in the hippocampus.
- What is Dihexa used for?
- Reported uses include strong synaptogenesis in rodent models and proposed nootropic use. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Dihexa dosed?
- Commonly referenced dosing is 8 – 20 mg (research), typically daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Dihexa?
- Commonly reported side effects include unknown in humans. This list is not exhaustive.
- Is Dihexa legal?
- No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established. FDA status: Not FDA-approved..