§ 01 Overview
Overview
Angiotensin IV analog with potent synaptogenic activity in preclinical models; potency much higher than BDNF in some assays.
Rodent data only. No human trials.
§ 02 Mechanism
Mechanism of action
Dihexa binds and activates HGF/c-Met signaling, promoting dendritic spine formation and synaptogenesis in the hippocampus.
- 01Strong synaptogenesis in rodent models
- 02Proposed nootropic use
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 8 – 20 mg (research)
- Route
- Oral
- Frequency
- Daily
- Cycle
- Short cycles
§ 04 Evidence
Evidence & research
Rodent data only. No human trials.
FDA Status
Not FDA-approved.
§ 06 News
In the news
2 articles from the last 12 months · updates hourly
Nootropics, Neurohacking and the Science of Cognitive Peptides: What Researchers Are Actually Finding - Programming Insider
Nootropics, Neurohacking and the Science of Cognitive Peptides: What Researchers Are Actually Finding Programming Insider
Integrative Health Miami Advances Personalized Nootropic Peptide Therapies for Cognitive Wellness - Daytona Beach News-Journal
Integrative Health Miami Advances Personalized Nootropic Peptide Therapies for Cognitive Wellness Daytona Beach News-Journal
§ 07 Sourcing
Sourcing & supply
Regulatory status
Research-only, no commercial channel
No commercial channel exists. Available only as a research reagent from RUO suppliers. Use in humans is not established.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Unknown in humans
Contraindications
- 01Active or prior cancer