§ 01 Overview
Overview
Khavinson brain-cortex tetrapeptide (AEDP) derived from Cortexin extract. Regulates nerve-regeneration genes and modulates IL-2 mRNA.
Russian-lab publications; limited Western replication.
§ 02 Mechanism
Mechanism of action
Cortagen is a short bioregulator peptide proposed to bind gene-regulatory regions and upregulate nerve-regeneration genes. It modulates IL-2 mRNA levels and shows activity in decondensing heterochromatin in senescent lymphocytes.
- 01Russian clinical and preclinical signal in peripheral neuropathy
- 02Immune modulation
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 5 – 10 mg per course
- Route
- SubQ
- Frequency
- Daily for 10–20 days
- Cycle
- 1–2 courses per year
§ 04 Evidence
Evidence & research
Russian-lab publications; limited Western replication.
FDA Status
Not FDA-approved.
§ 06 News
In the news
8 articles from the last 12 months · updates hourly
AEDP says HUD move to Alexandria finishes by year-end - The Alexandria Brief
AEDP says HUD move to Alexandria finishes by year-end The Alexandria Brief
AEDP reports a strong year. City Council members had questions about Potomac Yard - The Alexandria Brief
AEDP reports a strong year. City Council members had questions about Potomac Yard The Alexandria Brief
MU clears AEDP syllabus, pushes skill-based learning under SEP - The Times of India
MU clears AEDP syllabus, pushes skill-based learning under SEP The Times of India
Alexandria Lands $200,000 State Grant to Help Tech Startups Grow. Here's What It Means for Local Businesses - Alexandria Living Magazine
Alexandria Lands $200,000 State Grant to Help Tech Startups Grow. Here's What It Means for Local Businesses Alexandria Living Magazine
Earn Rs 12,300 Per Month While Studying: BRABU Launches 7 Degree Courses With Apprenticeship - Patna Press
Earn Rs 12,300 Per Month While Studying: BRABU Launches 7 Degree Courses With Apprenticeship Patna Press
Alexandria's business community gathers as AEDP tallies first results of ALX Forward - The Alexandria Brief
Alexandria's business community gathers as AEDP tallies first results of ALX Forward The Alexandria Brief
Alexandria's office vacancy falls to 18.8%, but Old Town's is rising - The Alexandria Brief
Alexandria's office vacancy falls to 18.8%, but Old Town's is rising The Alexandria Brief
SCCZ exchanges MoU for AEDP in Arunachal - The Arunachal Times
SCCZ exchanges MoU for AEDP in Arunachal The Arunachal Times
§ 07 Sourcing
Sourcing & supply
Regulatory status
Authentic supply from international sources
Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product.
International · 2
Cosmic Nootropic
The most credible Russian / Khavinson source for US buyers. Sources authentic bioregulators through 'Peptides Company' (ex-NPCRIZ).
Rupharma
12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.
Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →
§ 09 Safety
Safety & side effects
Side effects
- 01Limited published data
Contraindications
None specified.
§ 10 Questions
Cortagen FAQ
- What is Cortagen?
- Khavinson brain-cortex tetrapeptide (AEDP) derived from Cortexin extract. Regulates nerve-regeneration genes and modulates IL-2 mRNA. Cortagen is a short bioregulator peptide proposed to bind gene-regulatory regions and upregulate nerve-regeneration genes. It modulates IL-2 mRNA levels and shows activity in decondensing heterochromatin in senescent lymphocytes.
- What is Cortagen used for?
- Reported uses include russian clinical and preclinical signal in peripheral neuropathy and immune modulation. Evidence strength is rated Preclinical — see the evidence section for detail.
- How is Cortagen dosed?
- Commonly referenced dosing is 5 – 10 mg per course, typically daily for 10–20 days, administered SubQ. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Cortagen?
- Commonly reported side effects include limited published data. This list is not exhaustive.
- Is Cortagen legal?
- Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product. FDA status: Not FDA-approved..
§ 11 References
Selected references
- 01
IL-2 activation
PMID: 15723147
- 02
Heterochromatin decondensation
PMID: 19526184