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ClinicalCognitiveOralDaily

Noopept

GVS-111 · N-phenylacetyl-L-prolylglycine ethyl ester

Dipeptide-ester nootropic (Russian Rx) that metabolizes to cycloprolylglycine and elevates BDNF/NGF.

§ 01   Overview

Overview

Dipeptide-ester nootropic (Russian Rx) that metabolizes to cycloprolylglycine and elevates BDNF/NGF.

Russian clinical literature (Ostrovskaya 2002, 2007).

§ 02   Mechanism

Mechanism of action

Noopept is hydrolyzed to cycloprolylglycine, an endogenous dipeptide that stabilizes BDNF/NGF and exerts anxiolytic and anti-amnestic effects. It is used in Russia for cognitive decline and post-concussive states.

  • 01Anti-amnestic effects (preclinical and Russian clinical)
  • 02Anxiolytic at low doses
  • 03Oral bioavailability

§ 03   Dosing

Dosing protocol

Standard Protocol

Dose Range
10 – 30 mg daily
Route
Oral
Timing
AM or split AM/PM
Frequency
Daily
Cycle
4–8 weeks

§ 04   Evidence

Evidence & research

Clinical

Russian clinical literature (Ostrovskaya 2002, 2007).

FDA Status

Not FDA-approved. Registered in Russia for cognitive decline.

§ 07   Sourcing

Sourcing & supply

Regulatory status

Authentic supply from international sources

Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product.

International · 2

International

Cosmic Nootropic

The most credible Russian / Khavinson source for US buyers. Sources authentic bioregulators through 'Peptides Company' (ex-NPCRIZ).

Visit
International

Rupharma

12+ year Russian pharmacy reseller. Reviews.io 4.84/5 (81+). Has a genuine US warehouse for common peptides.

Visit

Listings are informational, not endorsement. Verify credentials and flags against FDA and PCAB databases before purchasing. Full directory & how to verify →

§ 09   Safety

Safety & side effects

Side effects

  • 01Irritability in some users
  • 02Headache
  • 03Sleep disruption at higher doses

Contraindications

None specified.

§ 10   Questions

Noopept FAQ

What is Noopept?
Dipeptide-ester nootropic (Russian Rx) that metabolizes to cycloprolylglycine and elevates BDNF/NGF. Noopept is hydrolyzed to cycloprolylglycine, an endogenous dipeptide that stabilizes BDNF/NGF and exerts anxiolytic and anti-amnestic effects. It is used in Russia for cognitive decline and post-concussive states.
What is Noopept used for?
Reported uses include anti-amnestic effects (preclinical and russian clinical), anxiolytic at low doses, and oral bioavailability. Evidence strength is rated Clinical — see the evidence section for detail.
How is Noopept dosed?
Commonly referenced dosing is 10 – 30 mg daily, administered Oral. This is educational reference only; consult a licensed clinician before use.
What are the side effects of Noopept?
Commonly reported side effects include irritability in some users, headache, and sleep disruption at higher doses. This list is not exhaustive.
Is Noopept legal?
Authentic product originates from specific international manufacturers, most commonly Russian pharmaceutical facilities for Khavinson bioregulators. RUO vendors selling the same name are typically Chinese-synthesized research vials, not the original product. FDA status: Not FDA-approved. Registered in Russia for cognitive decline..

§ 11   References

Selected references

  1. 01

    Ostrovskaya Exp Clin Pharmacol 2002

    PMID: 12596357

  2. 02

    Ostrovskaya 2007

    PMID: 17538146

This site is for educational and research purposes only. It does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide or supplement.