§ 01 Overview
Overview
Oral triple monoamine reuptake inhibitor investigated for obesity; shows substantial weight loss in trials.
Phase II weight-loss trials and Phase III for hypothalamic obesity.
§ 02 Mechanism
Mechanism of action
Tesofensine inhibits reuptake of serotonin, dopamine, and norepinephrine, producing appetite suppression and energy expenditure effects.
- 01Significant weight loss in Phase II
- 02Being studied in hypothalamic obesity
§ 03 Dosing
Dosing protocol
Standard Protocol
- Dose Range
- 250 – 500 mcg daily (trial doses)
- Route
- Oral
- Frequency
- Daily
- Cycle
- 8–24 weeks (trials)
§ 04 Evidence
Evidence & research
Phase II weight-loss trials and Phase III for hypothalamic obesity.
FDA Status
Not FDA-approved. Investigational.
§ 06 News
In the news
1 article from the last 12 months · updates hourly
Umbrella Lab Announces Documentation And Traceability Update For Tesofensine Reference Material - Yahoo Finance
Umbrella Lab Announces Documentation And Traceability Update For Tesofensine Reference Material Yahoo Finance
§ 07 Sourcing
Sourcing & supply
Regulatory status
Investigational, no compounding path
Currently in active clinical trials. No compounding pathway. No brand product. The only US channels are RUO vendors that the FDA has targeted with warning letters. Assume any sourcing carries significant regulatory and quality risk.
No suppliers in our directory currently stock this compound. For investigational or research-only compounds, legitimate channels may not exist outside clinical trials.
Browse full supplier directory§ 09 Safety
Safety & side effects
Side effects
- 01Elevated heart rate and blood pressure
- 02Dry mouth, insomnia
- 03Monoaminergic interactions
Contraindications
None specified.
§ 10 Questions
Tesofensine FAQ
- What is Tesofensine?
- Oral triple monoamine reuptake inhibitor investigated for obesity; shows substantial weight loss in trials. Tesofensine inhibits reuptake of serotonin, dopamine, and norepinephrine, producing appetite suppression and energy expenditure effects.
- What is Tesofensine used for?
- Reported uses include significant weight loss in phase ii and being studied in hypothalamic obesity. Evidence strength is rated Clinical — see the evidence section for detail.
- How is Tesofensine dosed?
- Commonly referenced dosing is 250 – 500 mcg daily (trial doses), administered Oral. This is educational reference only; consult a licensed clinician before use.
- What are the side effects of Tesofensine?
- Commonly reported side effects include elevated heart rate and blood pressure, dry mouth, insomnia, and monoaminergic interactions. This list is not exhaustive.
- Is Tesofensine legal?
- Currently in active clinical trials. No compounding pathway. No brand product. The only US channels are RUO vendors that the FDA has targeted with warning letters. Assume any sourcing carries significant regulatory and quality risk. FDA status: Not FDA-approved. Investigational..